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    Emerging roles of the tumor-associated stroma in promoting tumor metastasis.

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    Authors
    Horimoto, Y
    Polanska, Urszula M
    Takahashi, Y
    Orimo, Akira
    Affiliation
    Atopy Research Centre, Juntendo University School of Medicine, Tokyo, Japan.
    Issue Date
    2012
    
    Metadata
    Show full item record
    Abstract
    The stroma in human carcinomas consists of extracellular matrix and various types of non-carcinoma cells, mainly leukocytes, endothelial cells, fibroblasts, myofibroblasts and bone marrow-derived progenitors. The tumor-associated stroma actively supports tumor growth by stimulating neo-angiogenesis, as well as proliferation and invasion of apposed carcinoma cells. It has long been accepted that alterations within carcinoma cells mediate metastasis in a cell-autonomous fashion. Recent studies have, however, suggested an additional notion that cancer cells instigate local and systemic changes in the tumor microenvironment and contribute to niche formation for metastasis. Research, aiming to establish the roles of the tumor-associated stroma in facilitating the spread of carcinoma cells into distant organs, has provided an abundance of data and greater knowledge of the biology of metastatic carcinoma cells and associated stromal cells. This has stimulated further advances in the development of novel therapeutic approaches targeting tumor metastasis.
    Citation
    Emerging roles of the tumor-associated stroma in promoting tumor metastasis., 6 (3):193-202 Cell Adh Migr
    Journal
    Cell Adhesion & Migration
    URI
    http://hdl.handle.net/10541/262512
    DOI
    10.4161/cam.20631
    PubMed ID
    22568980
    Type
    Article
    Language
    en
    ISSN
    1933-6926
    ae974a485f413a2113503eed53cd6c53
    10.4161/cam.20631
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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