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    Targeted therapies in small cell lung cancer: a review.

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    Authors
    Abidin, Aidalena Z
    Garassino, M C
    Califano, Raffaele
    Harle, Amelie S
    Blackhall, Fiona H
    Affiliation
    Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, M20 4BX, UK.
    Issue Date
    2010-01
    
    Metadata
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    Abstract
    Small cell lung cancer (SCLC) is an aggressive form of lung cancer that is characterized by a rapid doubling time, early onset of dissemination and high sensitivity to chemotherapy. Despite the potential for cure in patients with limited disease with concurrent chemoradiation and an initial good response to chemotherapy in extensive disease, there is a high chance of disease relapse with an overall poor median survival for both stages. With increasing translational research and a better understanding of the molecular basis of cancer, a number of molecular targets have been identified in various preclinical studies. This review summarizes potentially viable targets and new agents that have been developed and employed in recent, ongoing and future clinical trials to attempt to improve clinical outcomes in this disease.
    Citation
    Targeted therapies in small cell lung cancer: a review. 2010, 2 (1):25-37 Ther Adv Med Oncol
    Journal
    Therapeutic Advances in Medical Oncology
    URI
    http://hdl.handle.net/10541/254644
    DOI
    10.1177/1758834009356014
    PubMed ID
    21789124
    Type
    Article
    Language
    en
    ISSN
    1758-8359
    ae974a485f413a2113503eed53cd6c53
    10.1177/1758834009356014
    Scopus Count
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