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    How many diseases are colorectal cancer?

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    Authors
    Greystoke, Alastair
    Mullamitha, Saifee A
    Affiliation
    Department of Medical Oncology, Christie NHS Foundation Trust, Manchester M20 4BX, UK ; School of Cancer and Imaging Sciences, University of Manchester, Manchester M13 9PL, UK.
    Issue Date
    2012
    
    Metadata
    Show full item record
    Abstract
    The development of personalised therapy and mechanism-targeted agents in oncology mandates the identification of the patient populations most likely to benefit from therapy. This paper discusses the increasing evidence as to the heterogeneity of the group of diseases called colorectal cancer. Differences in the aetiology and epidemiology of proximal and distal cancers are reflected in different clinical behaviour, histopathology, and molecular characteristics of these tumours. This may impact response both to standard cytotoxic therapies and mechanism-targeted agents. This disease heterogeneity leads to challenges in the design of clinical trials to assess novel therapies in the treatment of "colorectal cancer."
    Citation
    How many diseases are colorectal cancer? 2012, 2012:564741 Gastroenterol Res Pract
    Journal
    Gastroenterology Research and Practice
    URI
    http://hdl.handle.net/10541/254628
    DOI
    10.1155/2012/564741
    PubMed ID
    22991509
    Type
    Article
    Language
    en
    ISSN
    1687-630X
    ae974a485f413a2113503eed53cd6c53
    10.1155/2012/564741
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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