Affiliation
Department of Medical Oncology, Christie NHS Foundation Trust, Manchester M20 4BX, UK ; School of Cancer and Imaging Sciences, University of Manchester, Manchester M13 9PL, UK.Issue Date
2012
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Show full item recordAbstract
The development of personalised therapy and mechanism-targeted agents in oncology mandates the identification of the patient populations most likely to benefit from therapy. This paper discusses the increasing evidence as to the heterogeneity of the group of diseases called colorectal cancer. Differences in the aetiology and epidemiology of proximal and distal cancers are reflected in different clinical behaviour, histopathology, and molecular characteristics of these tumours. This may impact response both to standard cytotoxic therapies and mechanism-targeted agents. This disease heterogeneity leads to challenges in the design of clinical trials to assess novel therapies in the treatment of "colorectal cancer."Citation
How many diseases are colorectal cancer? 2012, 2012:564741 Gastroenterol Res PractJournal
Gastroenterology Research and PracticeDOI
10.1155/2012/564741PubMed ID
22991509Type
ArticleLanguage
enISSN
1687-630Xae974a485f413a2113503eed53cd6c53
10.1155/2012/564741
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