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    Assessing individual breast cancer risk within the U.K. National Health Service Breast Screening Program: a new paradigm for cancer prevention.

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    Authors
    Evans, D
    Warwick, J
    Astley, S
    Stavrinos, P
    Sahin, S
    Ingham, S
    McBurney, H
    Eckersley, B
    Harvie, M
    Wilson, M
    Beetles, U
    Warren, R
    Hufton, A
    Sergeant, J
    Newman, W
    Buchan, I
    Cuzick, J
    Howell, Anthony
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    Affiliation
    Genesis Prevention Centre and Nightingale Breast Screening Centre, University Hospital of South Manchester, UK.
    Issue Date
    2012-07
    
    Metadata
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    Abstract
    The aim of this study is to determine breast cancer risk at mammographic screening episodes and integrate standard risk factors with mammographic density and genetic data to assess changing the screening interval based on risk and offer women at high risk preventive strategies. We report our experience of assessing breast cancer risk within the U.K. National Health Service Breast Screening Program using results from the first 10,000 women entered into the "Predicting Risk Of breast Cancer At Screening" study. Of the first 28,849 women attending for screening at fifteen sites in Manchester 10,000 (35%) consented to study entry and completed the questionnaire. The median 10-year Tyrer-Cuzick breast cancer risk was 2.65% (interquartile range, 2.10-3.45). A total of 107 women (1.07%) had 10-year risks 8% or higher (high breast cancer risk), with a further 8.20% having moderately increased risk (5%-8%). Mammographic density (percent dense area) was 60% or more in 8.3% of women. We collected saliva samples from 478 women for genetic analysis and will extend this to 18% of participants. At time of consent to the study, 95.0% of women indicated they wished to know their risk. Women with a 10-year risk of 8% or more or 5% to 8% and mammographic density of 60% or higher were invited to attend or be telephoned to receive risk counseling; 81.9% of those wishing to know their risk have received risk counseling and 85.7% of these were found to be eligible for a risk-reducing intervention. These results confirm the feasibility of determining breast cancer risk and acting on the information in the context of population-based mammographic screening.
    Citation
    Assessing individual breast cancer risk within the U.K. National Health Service Breast Screening Program: a new paradigm for cancer prevention. 2012, 5 (7):943-51 Cancer Prev Res
    Journal
    Cancer Prevention Research
    URI
    http://hdl.handle.net/10541/254590
    DOI
    10.1158/1940-6207.CAPR-11-0458
    PubMed ID
    22581816
    Type
    Article
    Language
    en
    ISSN
    1940-6215
    ae974a485f413a2113503eed53cd6c53
    10.1158/1940-6207.CAPR-11-0458
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