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    Lack of Prognostic Effect of Carbonic Anhydrase-9, Hypoxia Inducible Factor-1α and Bcl-2 in 286 Patients with Early Squamous Cell Carcinoma of the Glottic Larynx Treated with Radiotherapy.

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    Authors
    Douglas, Catriona Mairi
    Bernstein, Jonathan M
    Ormston, V E
    Hall, R C
    Merve, Ashriwad
    Swindell, Ric
    Valentine, Helen R
    Slevin, Nicholas J
    West, Catharine M L
    Homer, J
    Affiliation
    Department of Surgery, The Christie NHS Foundation Trust, Manchester, UK; Radiotherapy Related Research, University of Manchester, Manchester, UK.
    Issue Date
    2012-07-25
    
    Metadata
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    Abstract
    AIMS: To evaluate the prognostic significance of potential tumour markers of hypoxia and apoptosis in early squamous cell carcinoma of the glottic larynx managed with radiotherapy. MATERIALS AND METHODS: In total, 382 patients with T1 and T2 squamous cell carcinoma of the glottic larynx (vocal cords) received radical radiotherapy (50-55 Gy, in 16 fractions in 98% of cases). Pre-treatment haemoglobin was available for 328 patients; biopsy samples were available for 286. Immunohistochemistry was carried out for carbonic anhydrase-9 (CA-9), hypoxia inducible factor-1α (HIF-1α) and Bcl-2. RESULTS: At 5 years, locoregional control was achieved in 88.2%, cancer-specific survival in 95.0% and overall survival in 78.7%. Adverse prognostic factors for locoregional tumour recurrence were pre-treatment haemoglobin <13.0 g/dl (P = 0.035, Log rank test; sensitivity 0.28, specificity 0.84) and stage T2 rather than T1 (P = 0.002). The effect of haemoglobin level on locoregional control was not significant when stratified by the median of 14.2 g/dl (P = 0.43) or as a continuous variable (P = 0.59). High CA-9 (P = 0.11), HIF-1α (P = 0.67) and Bcl-2 (P = 0.77) expression had no prognostic significance. CONCLUSIONS: High CA-9, HIF-1α and Bcl-2 do not add to the prognostic significance of tumour stage and lower haemoglobin in predicting failure of local control in early glottic larynx squamous cell carcinoma managed with radiotherapy. The effect of haemoglobin was not strong enough to be useful as a prognostic biomarker.
    Citation
    Lack of Prognostic Effect of Carbonic Anhydrase-9, Hypoxia Inducible Factor-1α and Bcl-2 in 286 Patients with Early Squamous Cell Carcinoma of the Glottic Larynx Treated with Radiotherapy. 2012:Clin Oncol (R Coll Radiol)
    Journal
    Clinical Oncology
    URI
    http://hdl.handle.net/10541/254587
    DOI
    10.1016/j.clon.2012.07.004
    PubMed ID
    22841149
    Type
    Article
    Language
    en
    ISSN
    1433-2981
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.clon.2012.07.004
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