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    Phase I study of the Aurora B kinase inhibitor barasertib (AZD1152) to assess the pharmacokinetics, metabolism and excretion in patients with acute myeloid leukemia.

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    Authors
    Dennis, Michael
    Davies, Michelle
    Oliver, S
    D'Souza, R
    Pike, L
    Stockman, P
    Affiliation
    The Christie NHS Foundation Trust, Manchester, UK. mike.dennis@christie.nhs.uk
    Issue Date
    2012-09
    
    Metadata
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    Abstract
    Barasertib (AZD1152) is a pro-drug that rapidly undergoes phosphatase-mediated cleavage in serum to release barasertib-hQPA, a selective Aurora B kinase inhibitor that has shown preliminary activity in clinical studies of patients with acute myeloid leukemia (AML). The pharmacokinetic (PK), metabolic and excretion profiles of barasertib and barasertib-hQPA were characterized in this open-label Phase I study.
    Citation
    Phase I study of the Aurora B kinase inhibitor barasertib (AZD1152) to assess the pharmacokinetics, metabolism and excretion in patients with acute myeloid leukemia. 2012, 70 (3):461-9 Cancer Chemother Pharmacol
    Journal
    Cancer Chemotherapy and Pharmacology
    URI
    http://hdl.handle.net/10541/254586
    DOI
    10.1007/s00280-012-1939-2
    PubMed ID
    22864876
    Type
    Article
    Language
    en
    ISSN
    1432-0843
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00280-012-1939-2
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