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    Efficacy and tolerability of limited field radiotherapy with concurrent capecitabine in locally advanced pancreatic cancer.

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    Authors
    Jackson, Andrew
    Jain, Pooja
    Watkins, Gillian R
    Whitfield, Gillian A
    Green, Melanie M
    Valle, Juan W
    Taylor, Malcolm B
    Dickinson, Clare
    Price, Patricia M
    Saleem, Azeem
    Affiliation
    Academic Radiation Oncology, The University of Manchester, Manchester, UK
    Issue Date
    2010
    
    Metadata
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    Abstract
    Aims: Patients with locally advanced pancreatic cancer (LAPC) are most commonly managed with chemotherapy or concurrent chemoradiotherapy (CRT), which may or may not include non-involved regional lymph nodes in the clinical target volume. We present our results of CRT for LAPC using capecitabine and delivering radiotherapy to a limited radiation field that excluded non-involved regional lymph nodes from the clinical target volume. Materials and methods: Thirty patients were studied. Patients received 50.4 Gy external beam radiotherapy in 28 fractions, delivered to a planning target volume expanded from the primary tumour and involved nodes only. Capecitabine (500e600 mg/m2) was given twice daily continuously during radiotherapy. Toxicity and efficacy data were prospectively collected. Results: Nausea, vomiting and tumour pain were the most common grade 2 toxicities. One patient developed grade 3 nausea. The median time to progression was 8.8 months, with 20% remaining progression free at 1 year. The median overall survival was 9.7 months with a 1 year survival of 30%. Of 21 patients with imaged progression, 13 (62%) progressed systemically, three (14%) had local progression, two (10%) had locoregional progression and three (14%) progressed with both local/locoregional and systemic disease. Conclusion: CRT using capecitabine and limited field radiotherapy is a well-tolerated, relatively efficacious treatment for LAPC. The low toxicity and low regional progression rates support the use of limited field radiotherapy, allowing evaluation of this regimen with other anti-cancer agents.
    Citation
    Efficacy and tolerability of limited field radiotherapy with concurrent capecitabine in locally advanced pancreatic cancer 2010, 22 (7):570 Clin Oncol
    Journal
    Clinical Oncology
    URI
    http://hdl.handle.net/10541/253039
    DOI
    10.1016/j.clon.2010.06.007
    Type
    Article
    Language
    en
    ISSN
    09366555
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.clon.2010.06.007
    Scopus Count
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