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dc.contributor.authorShenjere, Patrick
dc.contributor.authorEyden, Brian P
dc.contributor.authorBanerjee, Saumitra S
dc.contributor.authorChakrabarty, Bipasha
dc.contributor.authorShanks, Jonathan H
dc.contributor.authorSikand, Kanwal A
dc.contributor.authorMenasce, Lia P
dc.date.accessioned2012-11-12T17:13:07Z
dc.date.available2012-11-12T17:13:07Z
dc.date.issued2012-07-27
dc.identifier.citationUltrastructurally Confirmed Myofibrosarcoma: A Series of 10 New Cases, With a Discussion on Diagnostic Criteria. 2012:Int J Surg Patholen_GB
dc.identifier.issn1940-2465
dc.identifier.pmid22843641
dc.identifier.doi10.1177/1066896912454568
dc.identifier.urihttp://hdl.handle.net/10541/251893
dc.description.abstractSome view ultrastructure as key to myofibrosarcoma diagnosis, whereas others argue that electron microscopy is too little used in contemporary practice to be considered an important diagnostic tool. These views are discussed in the context of 10 ultrastructurally confirmed cases of myofibrosarcoma, some occurring at rare sites such as skin and penis. Patient age ranged from 21 to 83 years, with a 6:4 male to female ratio. Size ranged from 2 to 7.5 cm and all had infiltrative margins. Histologically, all consisted of variably cellular fascicles of spindle cells with mild to moderately pleomorphic nuclei, small punctate nucleoli, and eosinophilic cytoplasm. All cases showed α-smooth muscle actin positivity and 2 showed very focal weak positivity for desmin. Ultrastructurally, the tumor cells contained rough endoplasmic reticulum, mainly peripheral smooth-muscle myofilaments, and fibronectin fibrils or fibronexus junctions at the cell surface. The most confident diagnosis of myofibrosarcoma is provided by ultrastructural examination. However, given the right histological appearance, use of a panel of antibodies that includes α-smooth muscle actin, desmin, and h-caldesmon, serves as an acceptable practical way of diagnosing myofibrosarcoma.
dc.languageENG
dc.language.isoenen
dc.rightsArchived with thanks to International journal of surgical pathologyen_GB
dc.titleUltrastructurally Confirmed Myofibrosarcoma: A Series of 10 New Cases, With a Discussion on Diagnostic Criteria.en
dc.typeArticleen
dc.contributor.departmentChristie Hospital, Manchester, United Kingdomen_GB
dc.identifier.journalInternational Journal of Surgical Pathologyen_GB
html.description.abstractSome view ultrastructure as key to myofibrosarcoma diagnosis, whereas others argue that electron microscopy is too little used in contemporary practice to be considered an important diagnostic tool. These views are discussed in the context of 10 ultrastructurally confirmed cases of myofibrosarcoma, some occurring at rare sites such as skin and penis. Patient age ranged from 21 to 83 years, with a 6:4 male to female ratio. Size ranged from 2 to 7.5 cm and all had infiltrative margins. Histologically, all consisted of variably cellular fascicles of spindle cells with mild to moderately pleomorphic nuclei, small punctate nucleoli, and eosinophilic cytoplasm. All cases showed α-smooth muscle actin positivity and 2 showed very focal weak positivity for desmin. Ultrastructurally, the tumor cells contained rough endoplasmic reticulum, mainly peripheral smooth-muscle myofilaments, and fibronectin fibrils or fibronexus junctions at the cell surface. The most confident diagnosis of myofibrosarcoma is provided by ultrastructural examination. However, given the right histological appearance, use of a panel of antibodies that includes α-smooth muscle actin, desmin, and h-caldesmon, serves as an acceptable practical way of diagnosing myofibrosarcoma.


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