A novel scalable and stereospecific synthesis of 3α- and 3β-amino-5α-androstan-17-ones and 3α- and 3β-amino-5α-pregnan-20-ones.
Affiliation
Cancer Research UK Drug Discovery Unit, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, United KingdomIssue Date
2012
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Anovelscalable stereoselective synthesis of 3α- and 3β-amino-5α-androstan-17-ones and 3α- and 3β-amino-5α-pregnan-20-ones has been developed using phthalimide based Mitsunobu chemistry. In all four cases, the products were isolated as single diastereoisomers in high chemical yield and purity without the need for chromatography at any stage in their syntheses.Citation
A novel scalable and stereospecific synthesis of 3α- and 3β-amino-5α-androstan-17-ones and 3α- and 3β-amino-5α-pregnan-20-ones. 2012, 53 (23):2868 Tetrahedron LettersJournal
Tetrahedron LettersDOI
10.1016/j.tetlet.2012.03.124Type
ArticleLanguage
enISSN
00404039ae974a485f413a2113503eed53cd6c53
10.1016/j.tetlet.2012.03.124