Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis.
Authors
Pavlides, SVera, I
Gandara, Ricardo
Sneddon, Sharon
Pestell, R G
Mercier, I
Martinez-Outschoorn, U E
Whitaker-Menezes, D
Howell, Anthony
Sotgia, Federica
Lisanti, Michael P
Affiliation
Department of Stem Cell Biology & Regenerative Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, PA 19107, USA.Issue Date
2012-06-01
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Here, we review certain recent advances in oxidative stress and tumor metabolism, which are related to understanding the contributions of the microenvironment in promoting tumor growth and metastasis. In the early 1920s, Otto Warburg, a Nobel Laureate, formulated a hypothesis to explain the "fundamental basis" of cancer, based on his observations that tumors displayed a metabolic shift toward glycolysis. In 1963, Christian de Duve, another Nobel Laureate, first coined the phrase auto-phagy, derived from the Greek words "auto" and "phagy," meaning "self" and "eating." RECENT ADVANCES: Now, we see that these two ideas (autophagy and aerobic glycolysis) physically converge in the tumor stroma. First, cancer cells secrete hydrogen peroxide. Then, as a consequence, oxidative stress in cancer-associated fibroblasts drives autophagy, mitophagy, and aerobic glycolysis.Citation
Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis. 2012, 16 (11):1264-84 Antioxid Redox SignalJournal
Antioxidants & Redox SignalingDOI
10.1089/ars.2011.4243PubMed ID
21883043Type
ArticleLanguage
enISSN
1557-7716ae974a485f413a2113503eed53cd6c53
10.1089/ars.2011.4243
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