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    Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis.

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    Authors
    Pavlides, S
    Vera, I
    Gandara, Ricardo
    Sneddon, Sharon
    Pestell, R G
    Mercier, I
    Martinez-Outschoorn, U E
    Whitaker-Menezes, D
    Howell, Anthony
    Sotgia, Federica
    Lisanti, Michael P
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    Affiliation
    Department of Stem Cell Biology & Regenerative Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, PA 19107, USA.
    Issue Date
    2012-06-01
    
    Metadata
    Show full item record
    Abstract
    Here, we review certain recent advances in oxidative stress and tumor metabolism, which are related to understanding the contributions of the microenvironment in promoting tumor growth and metastasis. In the early 1920s, Otto Warburg, a Nobel Laureate, formulated a hypothesis to explain the "fundamental basis" of cancer, based on his observations that tumors displayed a metabolic shift toward glycolysis. In 1963, Christian de Duve, another Nobel Laureate, first coined the phrase auto-phagy, derived from the Greek words "auto" and "phagy," meaning "self" and "eating." RECENT ADVANCES: Now, we see that these two ideas (autophagy and aerobic glycolysis) physically converge in the tumor stroma. First, cancer cells secrete hydrogen peroxide. Then, as a consequence, oxidative stress in cancer-associated fibroblasts drives autophagy, mitophagy, and aerobic glycolysis.
    Citation
    Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis. 2012, 16 (11):1264-84 Antioxid Redox Signal
    Journal
    Antioxidants & Redox Signaling
    URI
    http://hdl.handle.net/10541/251816
    DOI
    10.1089/ars.2011.4243
    PubMed ID
    21883043
    Type
    Article
    Language
    en
    ISSN
    1557-7716
    ae974a485f413a2113503eed53cd6c53
    10.1089/ars.2011.4243
    Scopus Count
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