Epigenetic inactivation of TWIST2 in acute lymphoblastic leukemia modulates proliferation, cell survival and chemosensitivity.
Authors
Thathia, S HFerguson, S
Gautrey, H E
van Otterdijk, S D
Hili, M
Rand, V
Moorman, A V
Meyer, Stefan
Brown, R
Strathdee, G
Affiliation
Crucible Laboratory, Institute for Ageing and Health, Newcastle University, Newcastle-upon-Tyne, NE1 3BZ, UK.Issue Date
2012-03
Metadata
Show full item recordAbstract
Altered regulation of many transcription factors has been shown to be important in the development of leukemia. TWIST2 modulates the activity of a number of important transcription factors and is known to be a regulator of hematopoietic differentiation. Here, we investigated the significance of epigenetic regulation of TWIST2 in the control of cell growth and survival and in response to cytotoxic agents in acute lymphoblastic leukemia.Citation
Epigenetic inactivation of TWIST2 in acute lymphoblastic leukemia modulates proliferation, cell survival and chemosensitivity. 2012, 97 (3):371-8 HaematologicaJournal
HaematologicaDOI
10.3324/haematol.2011.049593PubMed ID
22058208Type
ArticleLanguage
enISSN
1592-8721ae974a485f413a2113503eed53cd6c53
10.3324/haematol.2011.049593
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