Chromosomal aberrations associated with clonal evolution and leukemic transformation in fanconi anemia: clinical and biological implications.
Affiliation
c/o Young Oncology Unit, Department of Paediatric and Adolescent Oncology, Christie Hospital, Wilmslow Road, Manchester M20 6XB, UK.Issue Date
2012
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Show full item recordAbstract
Fanconi anaemia (FA) is an inherited disease with congenital and developmental abnormalities, bone marrow failure, and extreme risk of leukemic transformation. Bone marrow surveillance is an important part of the clinical management of FA and often reveals cytogenetic aberrations. Here, we review bone marrow findings in FA and discuss the clinical and biological implications of chromosomal aberrations associated with leukemic transformation.Citation
Chromosomal aberrations associated with clonal evolution and leukemic transformation in fanconi anemia: clinical and biological implications. 2012, 2012:349837 AnemiaJournal
AnemiaDOI
10.1155/2012/349837PubMed ID
22675616Type
ArticleLanguage
enISSN
2090-1275ae974a485f413a2113503eed53cd6c53
10.1155/2012/349837
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