• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Latypov, Vitaly F
    Tubbs, J L
    Watson, Amanda J
    Marriott, Andrew S
    McGown, Gail
    Thorncroft, Mary R
    Wilkinson, O J
    Senthong, Pattama
    Butt, Amna
    Arvai, A S
    Millington, C L
    Povey, A C
    Williams, D M
    Santibanez-Koref, Mauro F
    Tainer, J A
    Margison, Geoffrey P
    Show allShow less
    Affiliation
    Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, UK.
    Issue Date
    2012-07-13
    
    Metadata
    Show full item record
    Abstract
    Nucleotide excision repair (NER) has long been known to remove DNA lesions induced by chemical carcinogens, and the molecular mechanism has been partially elucidated. Here we demonstrate that in Schizosaccharomyces pombe a DNA recognition protein, alkyltransferase-like 1 (Atl1), can play a pivotal role in selecting a specific NER pathway, depending on the nature of the DNA modification. The relative ease of dissociation of Atl1 from DNA containing small O(6)-alkylguanines allows accurate completion of global genome repair (GGR), whereas strong Atl1 binding to bulky O(6)-alkylguanines blocks GGR, stalls the transcription machinery, and diverts the damage to transcription-coupled repair. Our findings redraw the initial stages of the NER process in those organisms that express an alkyltransferase-like gene and raise the question of whether or not O(6)-alkylguanine lesions that are poor substrates for the alkyltransferase proteins in higher eukaryotes might, by analogy, signal such lesions for repair by NER.
    Citation
    Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines. 2012, 47 (1):50-60 Mol Cell
    Journal
    Molecular Cell
    URI
    http://hdl.handle.net/10541/251605
    DOI
    10.1016/j.molcel.2012.04.028
    PubMed ID
    22658721
    Type
    Article
    Language
    en
    ISSN
    1097-4164
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.molcel.2012.04.028
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-π interactions.
    • Authors: Wilkinson OJ, Latypov V, Tubbs JL, Millington CL, Morita R, Blackburn H, Marriott A, McGown G, Thorncroft M, Watson AJ, Connolly BA, Grasby JA, Masui R, Hunter CA, Tainer JA, Margison GP, Williams DM
    • Issue date: 2012 Nov 13
    • A novel DNA damage recognition protein in Schizosaccharomyces pombe.
    • Authors: Pearson SJ, Wharton S, Watson AJ, Begum G, Butt A, Glynn N, Williams DM, Shibata T, Santibáñez-Koref MF, Margison GP
    • Issue date: 2006
    • Synthesis of oligodeoxyribonucleotides containing a conformationally-locked anti analogue of O6-methyl-2'-deoxyguanosine and their recognition by MGMT and Atl1.
    • Authors: Abdu K, Aiertza MK, Wilkinson OJ, Grasby JA, Senthong P, Povey AC, Margison GP, Williams DM
    • Issue date: 2012 Nov 25
    • Role of alkyltransferase-like (ATL) protein in repair of methylated DNA lesions in Thermus thermophilus.
    • Authors: Onodera T, Morino K, Tokishita S, Morita R, Masui R, Kuramitsu S, Ohta T
    • Issue date: 2011 Mar
    • Alkyltransferase-like proteins.
    • Authors: Margison GP, Butt A, Pearson SJ, Wharton S, Watson AJ, Marriott A, Caetano CM, Hollins JJ, Rukazenkova N, Begum G, Santibáñez-Koref MF
    • Issue date: 2007 Aug 1
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.