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    ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response.

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    Authors
    Weston, Ria
    Peeters, Hanneke
    Ahel, Dragana
    Affiliation
    DNA Damage Response Group, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, United Kingdom.
    Issue Date
    2012-07-15
    
    Metadata
    Show full item record
    Abstract
    To efficiently duplicate their genomic content, cells must overcome DNA lesions that interfere with processive DNA replication. These lesions may be removed and repaired, rather than just tolerated, to allow continuity of DNA replication on an undamaged DNA template. However, it is unclear how this is achieved at a molecular level. Here we identify a new replication-associated factor, ZRANB3 (zinc finger, RAN-binding domain containing 3), and propose its role in the repair of replication-blocking lesions. ZRANB3 has a unique structure-specific endonuclease activity, which is coupled to ATP hydrolysis. It cleaves branched DNA structures with unusual polarity, generating an accessible 3'-OH group in the template of the leading strand. Furthermore, ZRANB3 localizes to DNA replication sites and interacts with the components of the replication machinery. It is recruited to damaged replication forks via multiple mechanisms, which involve interactions with PCNA, K63-polyubiquitin chains, and branched DNA structures. Collectively, our data support a role for ZRANB3 in the replication stress response and suggest new insights into how DNA repair is coordinated with DNA replication to maintain genome stability.
    Citation
    ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response. 2012, 26 (14):1558-72 Genes Dev
    Journal
    Genes & Development
    URI
    http://hdl.handle.net/10541/251590
    DOI
    10.1101/gad.193516.112
    PubMed ID
    22759634
    Type
    Article
    Language
    en
    ISSN
    1549-5477
    ae974a485f413a2113503eed53cd6c53
    10.1101/gad.193516.112
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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