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    The S. pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1.

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    Authors
    Grallert, Agnes
    Connolly, Yvonne
    Smith, Duncan L
    Simanis, Viesturs
    Hagan, Iain M
    Affiliation
    CRUK Cell Division Group, Paterson Institute for Cancer Research, Wilmslow Road, Manchester M20 4BX, UK.
    Issue Date
    2012-07
    
    Metadata
    Show full item record
    Abstract
    Mitotic exit integrates the reversal of the phosphorylation events initiated by mitotic kinases with a controlled cytokinesis event that cleaves the cell in two. The mitotic exit network (MEN) of budding yeast regulates both processes, whereas the fission yeast equivalent, the septum initiation network (SIN), controls only the execution of cytokinesis. The components and architecture of the SIN and MEN are highly conserved. At present, it is assumed that the functions of the core SIN-MEN components are restricted to their characterized roles at the end of mitosis. We now show that the NDR (nuclear Dbf2-related) kinase component of the fission yeast SIN, Sid2-Mob1, acts independently of the other known SIN components in G2 phase of the cell cycle to control the timing of mitotic commitment. Sid2-Mob1 promotes mitotic commitment by directly activating the NIMA (Never In Mitosis)-related kinase Fin1. Fin1's activation promotes its own destruction, thereby making Fin1 activation a transient feature of G2 phase. This spike of Fin1 activation modulates the activity of the Pom1/Cdr1/Cdr2 geometry network towards Wee1.
    Citation
    The S. pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1. 2012, 14 (7):738-45 Nat Cell Biol
    Journal
    Nature Cell Biology
    URI
    http://hdl.handle.net/10541/251567
    DOI
    10.1038/ncb2514
    PubMed ID
    22684255
    Type
    Article
    Language
    en
    ISSN
    1476-4679
    ae974a485f413a2113503eed53cd6c53
    10.1038/ncb2514
    Scopus Count
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    All Paterson Institute for Cancer Research

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