CAR-T cells and solid tumors: tuning T cells to challenge an inveterate foe.
AffiliationClinical and Experimental Immunotherapy Group, School of Cancer and Enabling Sciences, The University of Manchester, Withington, Manchester M20 4BX, UK. firstname.lastname@example.org
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AbstractRecent reports on the impressive efficacy of adoptively transferred T cells to challenge cancer in early phase clinical trials have significantly raised the profile of T cell therapy. Concomitantly, general expectations are also raised by these reports, with the natural aspiration to deliver this therapy over a wide range of tumor indications. Chimeric antigen receptors (CARs) endow T cell populations with defined antigen specificities that function independently of the natural T cell receptor and permit targeting of T cells towards virtually any tumor. Here, we review the current clinical application of CAR-T cells and relate clinical efficacy and safety of CAR-T cell trials to parameters considered critical for CAR engineering, classified as the three T's of CAR-T cell manipulation.
CitationCAR-T cells and solid tumors: tuning T cells to challenge an inveterate foe. 2012, 18 (7):377-84 Trends Mol Med
JournalTrends in Molecular Medicine
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