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dc.contributor.authorNilsson, Sofie
dc.contributor.authorMöller, C
dc.contributor.authorJirström, K
dc.contributor.authorLee, Alexander
dc.contributor.authorBusch, Susann
dc.contributor.authorLamb, Rebecca
dc.contributor.authorLandberg, Göran
dc.date.accessioned2012-08-29T15:34:36Z
dc.date.available2012-08-29T15:34:36Z
dc.date.issued2012
dc.identifier.citationDownregulation of miR-92a is associated with aggressive breast cancer features and increased tumour macrophage infiltration. 2012, 7 (4):e36051 PLoS ONEen_GB
dc.identifier.issn1932-6203
dc.identifier.pmid22563438
dc.identifier.doi10.1371/journal.pone.0036051
dc.identifier.urihttp://hdl.handle.net/10541/240471
dc.description.abstractMicroRNAs are small non-coding RNAs involved in the regulation of gene expression on a posttranscriptional level. These regulatory RNAs have been implicated in numerous cellular processes and are further deregulated in different cancer types, including breast cancer. MiR-92a is part of the miR-17∼92 cluster, which was first reported to be linked to tumourigenesis. However, little is known about the expression of miR-92a in breast cancer and potential associations to tumour properties. The expression of miR-92a was therefore characterized in 144 invasive breast cancer samples using in situ hybridization and related to clinico-pathological data as well as to selected key properties of the tumour stroma, including the presence of macrophages (CD68) and cancer activated fibroblasts (alpha-SMA).
dc.language.isoenen
dc.rightsArchived with thanks to PloS oneen_GB
dc.titleDownregulation of miR-92a is associated with aggressive breast cancer features and increased tumour macrophage infiltration.en
dc.typeArticleen
dc.contributor.departmentCenter for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skåne University Hospital, Malmö, Sweden.en_GB
dc.identifier.journalPloS ONEen_GB
html.description.abstractMicroRNAs are small non-coding RNAs involved in the regulation of gene expression on a posttranscriptional level. These regulatory RNAs have been implicated in numerous cellular processes and are further deregulated in different cancer types, including breast cancer. MiR-92a is part of the miR-17∼92 cluster, which was first reported to be linked to tumourigenesis. However, little is known about the expression of miR-92a in breast cancer and potential associations to tumour properties. The expression of miR-92a was therefore characterized in 144 invasive breast cancer samples using in situ hybridization and related to clinico-pathological data as well as to selected key properties of the tumour stroma, including the presence of macrophages (CD68) and cancer activated fibroblasts (alpha-SMA).


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