Downregulation of miR-92a is associated with aggressive breast cancer features and increased tumour macrophage infiltration.
AffiliationCenter for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skåne University Hospital, Malmö, Sweden.
MetadataShow full item record
AbstractMicroRNAs are small non-coding RNAs involved in the regulation of gene expression on a posttranscriptional level. These regulatory RNAs have been implicated in numerous cellular processes and are further deregulated in different cancer types, including breast cancer. MiR-92a is part of the miR-17∼92 cluster, which was first reported to be linked to tumourigenesis. However, little is known about the expression of miR-92a in breast cancer and potential associations to tumour properties. The expression of miR-92a was therefore characterized in 144 invasive breast cancer samples using in situ hybridization and related to clinico-pathological data as well as to selected key properties of the tumour stroma, including the presence of macrophages (CD68) and cancer activated fibroblasts (alpha-SMA).
CitationDownregulation of miR-92a is associated with aggressive breast cancer features and increased tumour macrophage infiltration. 2012, 7 (4):e36051 PLoS ONE
- MicroRNA-92a contributes to tumor growth of human hepatocellular carcinoma by targeting FBXW7.
- Authors: Yang W, Dou C, Wang Y, Jia Y, Li C, Zheng X, Tu K
- Issue date: 2015 Nov
- MiR-92a Promotes Cell Metastasis of Colorectal Cancer Through PTEN-Mediated PI3K/AKT Pathway.
- Authors: Ke TW, Wei PL, Yeh KT, Chen WT, Cheng YW
- Issue date: 2015 Aug
- Dysregulated miR-183 inhibits migration in breast cancer cells.
- Authors: Lowery AJ, Miller N, Dwyer RM, Kerin MJ
- Issue date: 2010 Sep 21
- miR-187 is an independent prognostic factor in breast cancer and confers increased invasive potential in vitro.
- Authors: Mulrane L, Madden SF, Brennan DJ, Gremel G, McGee SF, McNally S, Martin F, Crown JP, Jirström K, Higgins DG, Gallagher WM, O'Connor DP
- Issue date: 2012 Dec 15
- Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development.
- Authors: Shigoka M, Tsuchida A, Matsudo T, Nagakawa Y, Saito H, Suzuki Y, Aoki T, Murakami Y, Toyoda H, Kumada T, Bartenschlager R, Kato N, Ikeda M, Takashina T, Tanaka M, Suzuki R, Oikawa K, Takanashi M, Kuroda M
- Issue date: 2010 May