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    Targeted immunotherapy of cancer with CAR T cells: achievements and challenges.

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    Authors
    Lipowska-Bhalla, Grazyna
    Gilham, David E
    Hawkins, Robert E
    Rothwell, Dominic G
    Affiliation
    Clinical and Experimental Immunotherapy Group, School of Cancer and Enabling Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
    Issue Date
    2012-07
    
    Metadata
    Show full item record
    Abstract
    The adoptive transfer of chimeric antigen receptor (CAR)-expressing T cells is a relatively new but promising approach in the field of cancer immunotherapy. This therapeutic strategy is based on the genetic reprogramming of T cells with an artificial immune receptor that redirects them against targets on malignant cells and enables their destruction by exerting T cell effector functions. There has been an explosion of interest in the use of CAR T cells as an immunotherapy for cancer. In the pre-clinical setting, there has been a considerable focus upon optimizing the structural and signaling potency of the CAR while advances in bio-processing technology now mean that the clinical testing of these gene-modified T cells has become a reality. This review will summarize the concept of CAR-based immunotherapy and recent clinical trial activity and will further discuss some of the likely future challenges facing CAR-modified T cell therapies.
    Citation
    Targeted immunotherapy of cancer with CAR T cells: achievements and challenges. 2012, 61 (7):953-62 Cancer Immunol Immunother
    Journal
    Cancer Immunology Immunotherapy
    URI
    http://hdl.handle.net/10541/240459
    DOI
    10.1007/s00262-012-1254-0
    PubMed ID
    22527245
    Type
    Article
    Language
    en
    ISSN
    1432-0851
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00262-012-1254-0
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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