Dickkopf1 regulates fate decision and drives breast cancer stem cells to differentiation: an experimentally supported mathematical model.
Authors
Agur, ZKirnasovsky, O U
Vasserman, G
Tencer-Hershkowicz, L
Kogan, Y
Harrison, Hannah
Lamb, Rebecca
Clarke, Robert B
Affiliation
Institute for Medical BioMathematics, Bene Ataroth, Israel.Issue Date
2011
Metadata
Show full item recordAbstract
Modulation of cellular signaling pathways can change the replication/differentiation balance in cancer stem cells (CSCs), thus affecting tumor growth and recurrence. Analysis of a simple, experimentally verified, mathematical model suggests that this balance is maintained by quorum sensing (QS).Citation
Dickkopf1 regulates fate decision and drives breast cancer stem cells to differentiation: an experimentally supported mathematical model. 2011, 6 (9):e24225 PLoS ONEJournal
PloS OneDOI
10.1371/journal.pone.0024225PubMed ID
21915302Type
ArticleLanguage
enISSN
1932-6203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0024225
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