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The clinical features and outcome of 2009 H1N1 influenza infection in allo-SCT patients: a British Society of Blood and Marrow Transplantation study.

dc.contributor.authorProtheroe, R
dc.contributor.authorKirkland, K
dc.contributor.authorPearce, R
dc.contributor.authorKaminaris, K
dc.contributor.authorBloor, Adrian
dc.contributor.authorPotter, M
dc.contributor.authorNagra, S
dc.contributor.authorGilleece, M
dc.contributor.authorMcQuaker, I
dc.contributor.authorJackson, G
dc.contributor.authorCook, G
dc.contributor.authorMarks, D
dc.date.accessioned2012-06-26T12:22:32Z
dc.date.available2012-06-26T12:22:32Z
dc.date.issued2012-01
dc.identifier.citationThe clinical features and outcome of 2009 H1N1 influenza infection in allo-SCT patients: a British Society of Blood and Marrow Transplantation study. 2012, 47 (1):88-94 Bone Marrow Transplanten_GB
dc.identifier.issn1476-5365
dc.identifier.pmid21358686
dc.identifier.doi10.1038/bmt.2011.12
dc.identifier.urihttp://hdl.handle.net/10541/230812
dc.description.abstractThe clinical course of 2009 H1N1 influenza in Allo-SCT patients is unknown. Data were collected in the UK from October 2009 to April 2010 on laboratory-confirmed cases of H1N1 influenza in Allo-SCT recipients. H1N1 infection was diagnosed in 60 patients, median age 42 years, at a median of 10 months post-SCT. Twenty-one patients (35%) developed pneumonia and nine (15%) required admission to intensive care units. Actuarial mortality was 7% at 28 days and 19% 4 months post-diagnosis of 2009 H1N1 influenza. Increasing age and pre-existing lung disease were risk factors for pneumonia (P=0.006 and 0.037, respectively); older age was a risk factor for death (P=0.012). Morbidity and mortality from 2009 H1N1 influenza in SCT patients exceeds that of immunocompetent patients, but parallels that in other critically ill hospitalised cohorts; the elderly and those with chronic pulmonary disease are at greatest risk.
dc.language.isoenen
dc.rightsArchived with thanks to Bone marrow transplantationen_GB
dc.subject.meshInfluenza A Virus, H1N1 Subtype
dc.subject.meshInfluenza, Human
dc.subject.meshPandemics
dc.subject.meshPneumonia
dc.subject.meshStem Cell Transplantation
dc.titleThe clinical features and outcome of 2009 H1N1 influenza infection in allo-SCT patients: a British Society of Blood and Marrow Transplantation study.en
dc.typeArticleen
dc.contributor.departmentBristol Adult Bone Marrow Transplant Unit, University Hospitals Bristol, Bristol, UK.en_GB
dc.identifier.journalBone Marrow Transplantationen_GB
html.description.abstractThe clinical course of 2009 H1N1 influenza in Allo-SCT patients is unknown. Data were collected in the UK from October 2009 to April 2010 on laboratory-confirmed cases of H1N1 influenza in Allo-SCT recipients. H1N1 infection was diagnosed in 60 patients, median age 42 years, at a median of 10 months post-SCT. Twenty-one patients (35%) developed pneumonia and nine (15%) required admission to intensive care units. Actuarial mortality was 7% at 28 days and 19% 4 months post-diagnosis of 2009 H1N1 influenza. Increasing age and pre-existing lung disease were risk factors for pneumonia (P=0.006 and 0.037, respectively); older age was a risk factor for death (P=0.012). Morbidity and mortality from 2009 H1N1 influenza in SCT patients exceeds that of immunocompetent patients, but parallels that in other critically ill hospitalised cohorts; the elderly and those with chronic pulmonary disease are at greatest risk.


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