Carcinoma of unknown primary: key radiological issues from the recent National Institute for Health and Clinical Excellence guidelines.
Affiliation
Department of Radiology, The Christie NHS Foundation Trust, Manchester, UK.Issue Date
2012-06
Metadata
Show full item recordAbstract
Carcinoma of unknown primary origin (CUP) accounts for 3-5% of cancer cases and is the fourth most common cause of cancer death in the UK. CUP management is challenging, partly owing to the heterogeneity of the condition and its presentation, but also owing to the lack of dedicated clinical services for these patients. The recent National Institute for Health and Clinical Excellence (NICE) guidelines on metastatic malignancy of unknown primary origin were developed to improve the co-ordination of diagnostic and clinical services at hospitals treating cancer patients in England and Wales, in particular by the setting up of CUP teams to manage these patients. Radiologists have a vital role in the diagnosis of these patients and should work closely with the CUP team to streamline the diagnostic pathway. This article summarises areas of the NICE guidelines relevant to radiology and discusses the radiological management of patients with CUP, including initial investigation, the importance of biopsy, the management of specific presentations, special investigations and organisational issues.Citation
Carcinoma of unknown primary: key radiological issues from the recent National Institute for Health and Clinical Excellence guidelines. 2012, 85 (1014):661-71 Br J RadiolJournal
British Journal of RadiologyDOI
10.1259/bjr/75018360PubMed ID
22374278Type
ArticleLanguage
enISSN
1748-880Xae974a485f413a2113503eed53cd6c53
10.1259/bjr/75018360
Scopus Count
Collections
Related articles
- Impact on Patient Management of [18F]-Fluorodeoxyglucose-Positron Emission Tomography (PET) Used for Cancer Diagnosis: Analysis of Data From the National Oncologic PET Registry.
- Authors: Subramaniam RM, Shields AF, Sachedina A, Hanna L, Duan F, Siegel BA, Hillner BE
- Issue date: 2016 Sep
- FDG-PET/CT for detection of the unknown primary head and neck tumor.
- Authors: Johansen J, Petersen H, Godballe C, Loft A, Grau C
- Issue date: 2011 Oct
- PET and PET/CT for unknown primary tumors.
- Authors: Kwee TC, Basu S, Alavi A
- Issue date: 2011
- Role of 2-Fluoro-2-Deoxyglucose PET/Computed Tomography in Carcinoma of Unknown Primary.
- Authors: Pawaskar AS, Basu S
- Issue date: 2015 Jul
- [(18)F-fluorodeoxyglucose positron emission tomography/computed tomography and unknown origin primary tumor. Current usefulness and future perspectives].
- Authors: Duch J
- Issue date: 2013 Jan 5