A phase 1 trial of recombinant human IL-21 in combination with cetuximab in patients with metastatic colorectal cancer.
Authors
Steele, NAnthony, A
Saunders, Mark P
Esmarck, B
Ehrnrooth, E
Kristjansen, P
Nihlén, A
Hansen, L
Cassidy, J
Affiliation
CRUK Clinical Trials Unit, Beatson West of Scotland Cancer Centre, 1053 Great Western Road, Glasgow G12 0YN, UK. n.steele@nhs.netIssue Date
2012-02-28
Metadata
Show full item recordAbstract
Pre-clinical data indicate enhanced anti-tumour activity when combining recombinant human interleukin-21 (rIL-21), a class 1 cytokine, with cetuximab, a monoclonal antibody, targeting the epidermal growth factor receptor. This phase 1 trial assessed the safety and tolerability of escalating doses of rIL-21 in combination with cetuximab in chemo-naïve patients with stage IV colorectal cancer.Citation
A phase 1 trial of recombinant human IL-21 in combination with cetuximab in patients with metastatic colorectal cancer. 2012, 106 (5):793-8 Br J CancerJournal
British Journal of CancerDOI
10.1038/bjc.2011.599PubMed ID
22315057Type
ArticleLanguage
enISSN
1532-1827ae974a485f413a2113503eed53cd6c53
10.1038/bjc.2011.599
Scopus Count
Collections
Related articles
- A phase I escalating single-dose and weekly fixed-dose study of cetuximab pharmacokinetics in Japanese patients with solid tumors.
- Authors: Shirao K, Yoshino T, Boku N, Kato K, Hamaguchi T, Yasui H, Yamamoto N, Tanigawara Y, Nolting A, Yoshino S
- Issue date: 2009 Aug
- Phase I study of cetuximab, erlotinib, and bevacizumab in patients with advanced solid tumors.
- Authors: Lin CC, Calvo E, Papadopoulos KP, Patnaik A, Sarantopoulos J, Mita AC, Preston GG, Mita MM, Rodon J, Mays T, Yeh IT, O'Rourke P, Takimoto CH, Dancey JE, Chen H, Tolcher AW
- Issue date: 2009 May
- Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor.
- Authors: Saltz LB, Meropol NJ, Loehrer PJ Sr, Needle MN, Kopit J, Mayer RJ
- Issue date: 2004 Apr 1
- A phase I study of cetuximab/paclitaxel in patients with advanced-stage breast cancer.
- Authors: Modi S, D'Andrea G, Norton L, Yao TJ, Caravelli J, Rosen PP, Hudis C, Seidman AD
- Issue date: 2006 Aug
- Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer.
- Authors: Tabernero J, Van Cutsem E, Díaz-Rubio E, Cervantes A, Humblet Y, André T, Van Laethem JL, Soulié P, Casado E, Verslype C, Valera JS, Tortora G, Ciardiello F, Kisker O, de Gramont A
- Issue date: 2007 Nov 20