Is there a spectrum of cytologic atypia in type a thymomas analogous to that seen in type B thymomas? A pilot study of 13 cases.
| dc.contributor.author | Nonaka, Daisuke | |
| dc.contributor.author | Rosai, Juan | |
| dc.date.accessioned | 2012-06-22T10:31:02Z | |
| dc.date.available | 2012-06-22T10:31:02Z | |
| dc.date.issued | 2012-06 | |
| dc.identifier.citation | Is there a spectrum of cytologic atypia in type a thymomas analogous to that seen in type B thymomas? A pilot study of 13 cases. 2012, 36 (6):889-94 Am. J. Surg. Pathol. | en_GB |
| dc.identifier.issn | 1532-0979 | |
| dc.identifier.pmid | 22472953 | |
| dc.identifier.doi | 10.1097/PAS.0b013e31824fff50 | |
| dc.identifier.uri | http://hdl.handle.net/10541/230175 | |
| dc.description.abstract | Thirteen cases of type A thymoma are reported showing the characteristic architectural attributes of this tumor type (World Health Organization), such as lobulation, perivascular spaces, gland-like formations, and cystic changes, but also displaying atypical features, as defined by increased mitotic activity, mild to moderate nuclear atypia, and/or scattered small foci of necrosis. The tumors were similar to type B3 thymomas in many respects, except for the fact that the tumor cells were spindled instead of round/polygonal. The existence of these cases suggests the desirability of an expansion of the type A thymoma category, analogous to that currently used for type B tumors. The various nomenclature options that could be used to name these tumors have been discussed. | |
| dc.language.iso | en | en |
| dc.rights | Archived with thanks to The American journal of surgical pathology | en_GB |
| dc.title | Is there a spectrum of cytologic atypia in type a thymomas analogous to that seen in type B thymomas? A pilot study of 13 cases. | en |
| dc.type | Article | en |
| dc.contributor.department | *Department of Histopathology, The Christie Hospital †School of Cancer and Enabling Sciences, University of Manchester School of Medicine, Manchester, UK ‡Centro Diagnostico Italiano, Milan, Italy §Genzyme Genetics/LabCorp, New York, NY. | en_GB |
| dc.identifier.journal | American Journal of Surgical Pathology | en_GB |
| html.description.abstract | Thirteen cases of type A thymoma are reported showing the characteristic architectural attributes of this tumor type (World Health Organization), such as lobulation, perivascular spaces, gland-like formations, and cystic changes, but also displaying atypical features, as defined by increased mitotic activity, mild to moderate nuclear atypia, and/or scattered small foci of necrosis. The tumors were similar to type B3 thymomas in many respects, except for the fact that the tumor cells were spindled instead of round/polygonal. The existence of these cases suggests the desirability of an expansion of the type A thymoma category, analogous to that currently used for type B tumors. The various nomenclature options that could be used to name these tumors have been discussed. |