The roles of ATF2 (activating transcription factor 2) in tumorigenesis.
Affiliation
Cell Regulation Department, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Withington, Manchester M20 4BX, UK.Issue Date
2012-02-01
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Show full item recordAbstract
MAPK (mitogen-activated protein kinase) pathways are among the most frequently deregulated signalling events in cancer. Among the critical targets of MAPK activities are members of the AP-1 (activator protein 1) transcription factor, a dimeric complex consisting of Jun, Fos, Maf and ATF (activating transcription factor) family DNA-binding proteins. Depending on the cellular context, the composition of the dimeric complexes determines the regulation of growth, survival or apoptosis. JNK (c-Jun N-terminal kinase), p38 and a number of Jun and Fos family proteins have been analysed for their involvement in oncogenic transformation and tumour formation. These data are also emerging for the ATF components of the AP-1 factor. The aim of the present review is to provide an overview of the functions of two ATF family proteins, ATF2 and ATF7, in mammalian development and their potential functions in tumour formation.Citation
The roles of ATF2 (activating transcription factor 2) in tumorigenesis. 2012, 40 (1):230-4 Biochem Soc TransJournal
Biochemical Society TransactionsDOI
10.1042/BST20110630PubMed ID
22260696Type
ArticleLanguage
enISSN
1470-8752ae974a485f413a2113503eed53cd6c53
10.1042/BST20110630
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