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    The roles of ATF2 (activating transcription factor 2) in tumorigenesis.

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    Authors
    Gozdecka, Malgorzata
    Breitwieser, Wolfgang
    Affiliation
    Cell Regulation Department, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Withington, Manchester M20 4BX, UK.
    Issue Date
    2012-02-01
    
    Metadata
    Show full item record
    Abstract
    MAPK (mitogen-activated protein kinase) pathways are among the most frequently deregulated signalling events in cancer. Among the critical targets of MAPK activities are members of the AP-1 (activator protein 1) transcription factor, a dimeric complex consisting of Jun, Fos, Maf and ATF (activating transcription factor) family DNA-binding proteins. Depending on the cellular context, the composition of the dimeric complexes determines the regulation of growth, survival or apoptosis. JNK (c-Jun N-terminal kinase), p38 and a number of Jun and Fos family proteins have been analysed for their involvement in oncogenic transformation and tumour formation. These data are also emerging for the ATF components of the AP-1 factor. The aim of the present review is to provide an overview of the functions of two ATF family proteins, ATF2 and ATF7, in mammalian development and their potential functions in tumour formation.
    Citation
    The roles of ATF2 (activating transcription factor 2) in tumorigenesis. 2012, 40 (1):230-4 Biochem Soc Trans
    Journal
    Biochemical Society Transactions
    URI
    http://hdl.handle.net/10541/227794
    DOI
    10.1042/BST20110630
    PubMed ID
    22260696
    Type
    Article
    Language
    en
    ISSN
    1470-8752
    ae974a485f413a2113503eed53cd6c53
    10.1042/BST20110630
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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