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    A two-part phase II study of cediranib in patients with advanced solid tumours: the effect of food on single-dose pharmacokinetics and an evaluation of safety, efficacy and imaging pharmacodynamics.

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    Authors
    Mitchell, Claire L
    O'Connor, James P B
    Roberts, C
    Watson, Y
    Jackson, A
    Cheung, S
    Evans, J
    Spicer, J
    Harris, A
    Kelly, C
    Rudman, S
    Middleton, M
    Fielding, A
    Tessier, J
    Young, H
    Parker, G J M
    Jayson, Gordon C
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    Affiliation
    Department of Medical Oncology, Christie Hospital NHS Trust, Withington, Manchester, UK. Claire.Mitchell@christie.nhs.uk
    Issue Date
    2011-09
    
    Metadata
    Show full item record
    Abstract
    Cediranib (RECENTIN™) is an oral, highly potent VEGF inhibitor. This study evaluated the effect of food on the pharmacokinetics of cediranib and compared the administration of continual cediranib via two dosing strategies using this as a platform to investigate pharmacodynamic imaging biomarkers.
    Citation
    A two-part phase II study of cediranib in patients with advanced solid tumours: the effect of food on single-dose pharmacokinetics and an evaluation of safety, efficacy and imaging pharmacodynamics. 2011, 68 (3):631-41 Cancer Chemother Pharmacol
    Journal
    Cancer Chemotherapy and Pharmacology
    URI
    http://hdl.handle.net/10541/226214
    DOI
    10.1007/s00280-010-1534-3
    PubMed ID
    21120480
    Type
    Article
    Language
    en
    ISSN
    1432-0843
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00280-010-1534-3
    Scopus Count
    Collections
    All Christie Publications
    Medical Oncology

    entitlement

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