Affiliation
Cancer Research UK Stem Cell Hematopoiesis Group, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK; Graduate Program in Areas of Basic and Applied Biology (GABBA), University of Porto, Porto, Portugal.Issue Date
2012-02-23
Metadata
Show full item recordAbstract
Hematopoietic stem cells (HSCs) are capable of self-renewal and differentiation into all blood cell types. During adult life, they reside in the bone marrow in a quiescent state. By contrast, in the growing embryo hematopoiesis is sequentially found in several developmental niches. This review provides an overview of the still controversial contribution of each of these embryonic sites to the final pool of adult HSCs and discusses new insights into the cellular origin and the molecular regulation implicated in the generation of blood progenitor cells. A better understanding of HSC development during ontogeny is essential to develop new strategies to amplify HSCs or to generate them from embryonic stem cells or by somatic cell reprogramming.Citation
Origin of blood cells and HSC production in the embryo. 2012, 33(5):215-223 Trends ImmunolJournal
Trends in ImmunologyDOI
10.1016/j.it.2012.01.012PubMed ID
22365572Type
ArticleLanguage
enISSN
1471-4981ae974a485f413a2113503eed53cd6c53
10.1016/j.it.2012.01.012
Scopus Count
Collections
Related articles
- Development of the hematopoietic system: Role of inflammatory factors.
- Authors: Hayashi Y, Sezaki M, Takizawa H
- Issue date: 2019 Jul
- On the origin of hematopoietic stem cells: progress and controversy.
- Authors: Boisset JC, Robin C
- Issue date: 2012 Jan
- Capturing embryonic hematopoiesis in temporal and spatial dimensions.
- Authors: Weijts B, Robin C
- Issue date: 2024 Aug
- Development of Hematopoietic Stem Cells in the Early Mammalian Embryo.
- Authors: Rybtsov SA, Lagarkova MA
- Issue date: 2019 Mar
- Embryonic origin of human hematopoiesis.
- Authors: Tavian M, Biasch K, Sinka L, Vallet J, Péault B
- Issue date: 2010