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    A phase I study of sunitinib in combination with FOLFIRI in patients with untreated metastatic colorectal cancer.

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    Authors
    Starling, N
    Vázquez-Mazón, F
    Cunningham, D
    Chau, I
    Tabernero, J
    Ramos, F
    Iveson, T
    Saunders, Mark P
    Aranda, E
    Countouriotis, A
    Ruiz-Garcia, A
    Wei, G
    Tursi, J
    Guillen-Ponce, C
    Carrato, A
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    Affiliation
    Department of Medicine, Royal Marsden Hospital, NHS Foundation Trust, London and Sutton, UK.
    Issue Date
    2012-01
    
    Metadata
    Show full item record
    Abstract
    This study evaluated the maximum tolerated dose (MTD) of sunitinib, a multitargeted tyrosine kinase inhibitor, combined with FOLFIRI (irinotecan 180 mg/m2 given over 90 min i.v. and l-leucovorin 200 mg/m2 given over 120 min on day 1, followed by 5-FU 400 mg/m2 bolus and then 2400 mg/m2 infused over 46 h) in untreated metastatic colorectal cancer (mCRC).
    Citation
    A phase I study of sunitinib in combination with FOLFIRI in patients with untreated metastatic colorectal cancer. 2012, 23 (1):119-27 Ann Oncol
    Journal
    Annals of Oncology
    URI
    http://hdl.handle.net/10541/221357
    DOI
    10.1093/annonc/mdr046
    PubMed ID
    21447616
    Type
    Article
    Language
    en
    ISSN
    1569-8041
    ae974a485f413a2113503eed53cd6c53
    10.1093/annonc/mdr046
    Scopus Count
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