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    Comparison of serum cortisol measurement by immunoassay and liquid chromatography-tandem mass spectrometry in patients receiving the 11β-hydroxylase inhibitor metyrapone.

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    Authors
    Monaghan, Phillip J
    Owen, L J
    Trainer, Peter J
    Brabant, Georg E
    Keevil, B G
    Darby, Denise
    Affiliation
    Biochemistry Department, The Christie NHS Foundation Trust, Withington, Manchester M20 4BX, UK. phillip.monaghan@nhs.net
    Issue Date
    2011-09
    
    Metadata
    Show full item record
    Abstract
    The accurate measurement of cortisol by immunoassay is compromised by the potential for cross-reactivity of reagent antibodies with structurally related steroids present in serum. This susceptibility is potentiated when normal steroid metabolism is altered pharmaceutically by antisteroidogenic drugs utilized in the management of Cushing's syndrome to moderate cortisol production. The clinical implications of falsely elevated cortisol results include over-treatment and unrecognized hypoadrenalism. To investigate the effect of the 11β-hydroxylase inhibitor metyrapone on serum cortisol assay, a comparison of measurement by immunoassay versus liquid chromatography-tandem mass spectrometry (LC-MS/MS) was conducted.
    Citation
    Comparison of serum cortisol measurement by immunoassay and liquid chromatography-tandem mass spectrometry in patients receiving the 11β-hydroxylase inhibitor metyrapone. 2011, 48 (Pt 5):441-6 Ann Clin Biochem
    Journal
    Annals of Clinical Biochemistry
    URI
    http://hdl.handle.net/10541/219593
    DOI
    10.1258/acb.2011.011014
    PubMed ID
    21813575
    Type
    Article
    Language
    en
    ISSN
    1758-1001
    ae974a485f413a2113503eed53cd6c53
    10.1258/acb.2011.011014
    Scopus Count
    Collections
    All Christie Publications
    Endocrinology
    Pathology

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