The transcription factor Mxd4 controls the proliferation of the first blood precursors at the onset of hematopoietic development in vitro.
AffiliationCancer Research UK Stem Cell Hematopoiesis Group, Paterson Institute for Cancer Research, University of Manchester, UK.
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AbstractThe balance between proliferation and differentiation during hematopoietic development in the embryo is a complex process, the detailed molecular mechanisms of which remain to be fully characterized. The transcription factor Mxd4, a member of the Myc-Max-Mad network, was identified in a global gene expression profiling screen as being tightly regulated at the onset of hematopoietic lineage specification upon in vitro differentiation of mouse embryonic stem cells. Our study investigated the Mxd4 expression pattern at the onset of hematopoiesis and the biological relevance of its sharp and transient downregulation.
CitationThe transcription factor Mxd4 controls the proliferation of the first blood precursors at the onset of hematopoietic development in vitro. 2011, 39 (11):1090-100 Exp Hematol
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