Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and -independent approaches.

Authors
Krebs, Matthew G
Hou, Jian-Mei
Sloane, Robert
Lancashire, Lee J
Priest, Lynsey
Nonaka, Daisuke
Ward, Timothy H
Backen, Alison C
Clack, Glen
Hughes, Andrew
Ranson, Malcolm R
Blackhall, Fiona H
Dive, Caroline
Affiliation
Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, University of Manchester, United Kingdom.
Issue Date
2012-02

Metadata
Show full item record
Abstract
Epithelial circulating tumor cells (CTCs) are detectable in patients with non-small cell lung cancer (NSCLC). However, epithelial to mesenchymal transition, a widely reported prerequisite for metastasis, may lead to an underestimation of CTC number. We compared directly an epithelial marker-dependent (CellSearch) and a marker-independent (isolation by size of epithelial tumor cells [ISET]) technology platform for the ability to identify CTCs. Molecular characteristics of CTCs were also explored.
Citation
Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and -independent approaches. 2012, 7 (2):306-15 J Thorac Oncol
Journal
Journal of Thoracic Oncology
URI
http://hdl.handle.net/10541/216594
DOI
10.1097/JTO.0b013e31823c5c16
PubMed ID
22173704
Type
Article
Language
en
ISSN
1556-1380
Collections