Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and -independent approaches.
Authors
Krebs, Matthew GHou, Jian-Mei
Sloane, Robert
Lancashire, Lee J
Priest, Lynsey
Nonaka, Daisuke
Ward, Timothy H
Backen, Alison C
Clack, Glen
Hughes, Andrew
Ranson, Malcolm R
Blackhall, Fiona H
Dive, Caroline
Affiliation
Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, University of Manchester, United Kingdom.Issue Date
2012-02
Metadata
Show full item recordAbstract
Epithelial circulating tumor cells (CTCs) are detectable in patients with non-small cell lung cancer (NSCLC). However, epithelial to mesenchymal transition, a widely reported prerequisite for metastasis, may lead to an underestimation of CTC number. We compared directly an epithelial marker-dependent (CellSearch) and a marker-independent (isolation by size of epithelial tumor cells [ISET]) technology platform for the ability to identify CTCs. Molecular characteristics of CTCs were also explored.Citation
Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and -independent approaches. 2012, 7 (2):306-15 J Thorac OncolJournal
Journal of Thoracic OncologyDOI
10.1097/JTO.0b013e31823c5c16PubMed ID
22173704Type
ArticleLanguage
enISSN
1556-1380ae974a485f413a2113503eed53cd6c53
10.1097/JTO.0b013e31823c5c16
Scopus Count
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