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    Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and -independent approaches.

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    Authors
    Krebs, Matthew G
    Hou, Jian-Mei
    Sloane, Robert
    Lancashire, Lee J
    Priest, Lynsey
    Nonaka, Daisuke
    Ward, Timothy H
    Backen, Alison C
    Clack, Glen
    Hughes, Andrew
    Ranson, Malcolm R
    Blackhall, Fiona H
    Dive, Caroline
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    Affiliation
    Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, University of Manchester, United Kingdom.
    Issue Date
    2012-02
    
    Metadata
    Show full item record
    Abstract
    Epithelial circulating tumor cells (CTCs) are detectable in patients with non-small cell lung cancer (NSCLC). However, epithelial to mesenchymal transition, a widely reported prerequisite for metastasis, may lead to an underestimation of CTC number. We compared directly an epithelial marker-dependent (CellSearch) and a marker-independent (isolation by size of epithelial tumor cells [ISET]) technology platform for the ability to identify CTCs. Molecular characteristics of CTCs were also explored.
    Citation
    Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and -independent approaches. 2012, 7 (2):306-15 J Thorac Oncol
    Journal
    Journal of Thoracic Oncology
    URI
    http://hdl.handle.net/10541/216594
    DOI
    10.1097/JTO.0b013e31823c5c16
    PubMed ID
    22173704
    Type
    Article
    Language
    en
    ISSN
    1556-1380
    ae974a485f413a2113503eed53cd6c53
    10.1097/JTO.0b013e31823c5c16
    Scopus Count
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    All Christie Publications
    All Paterson Institute for Cancer Research
    Pathology

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