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    Targeted agents in non-small cell lung cancer (NSCLC): Clinical developments and rationale for the combination with thoracic radiotherapy.

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    Authors
    Koh, Pek K
    Faivre-Finn, Corinne
    Blackhall, Fiona H
    De Ruysscher, D
    Affiliation
    Department of Clinical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK.
    Issue Date
    2011-12-22
    
    Metadata
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    Abstract
    In recent years there has been undoubted progress in the evaluation and development of targeted agents for non-small cell lung cancer (NSCLC). A major contributor has been the discovery of molecular subtypes harbouring a critical oncogenic driver mutation, specifically sensitizing mutations in the epidermal growth factor receptor (EGFR) gene and the EML4-ALK gene translocation. Radiotherapy is a cornerstone of therapy for the curative intent treatment of early stage, localized disease; and for the palliation of symptoms in advanced, metastatic disease. In this molecular targeted era there is limited understanding of how best to combine targeted agents with radiotherapy and in general clinical studies with radiotherapy have lagged behind studies of targeted agents with chemotherapy. Here we summarise the progress made to date and highlight future directions.
    Citation
    Targeted agents in non-small cell lung cancer (NSCLC): Clinical developments and rationale for the combination with thoracic radiotherapy. 2011: Cancer Treat Rev
    Journal
    Cancer Treatment Reviews
    URI
    http://hdl.handle.net/10541/216298
    DOI
    10.1016/j.ctrv.2011.11.003
    PubMed ID
    22196919
    Type
    Article
    Language
    en
    ISSN
    1532-1967
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ctrv.2011.11.003
    Scopus Count
    Collections
    All Christie Publications
    Medical Oncology
    Clinical Oncology

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