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    Immunology in the clinic review series; focus on cancer: double trouble for tumours: bi-functional and redirected T cells as effective cancer immunotherapies.

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    Authors
    Marr, L A
    Gilham, David E
    Campbell, J D M
    Fraser, A R
    Affiliation
    Chemokine Research Group, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
    Issue Date
    2012-02
    
    Metadata
    Show full item record
    Abstract
    Cancer is one of the most important pathological conditions facing mankind in the 21st century, and is likely to become the most important cause of death as improvements continue in health, diet and life expectancy. The immune response is responsible for controlling nascent cancer through immunosurveillance. If tumours escape this control, they can develop into clinical cancer. Although surgery and chemo- or radiotherapy have improved survival rates significantly, there is a drive to reharness immune responses to treat disease. As T cells are one of the key immune cells in controlling cancer, research is under way to enhance their function and improve tumour targeting. This can be achieved by transduction with tumour-specific T cell receptor (TCR) or chimaeric antigen receptors (CAR) to generate redirected T cells. Virus-specific cells can also be transduced with TCR or CAR to create bi-functional T cells with specificity for both virus and tumour. In this review we outline the development and optimization of redirected and bi-functional T cells, and outline the results from current clinical trials using these cells. From this we discuss the challenges involved in generating effective anti-tumour responses while avoiding concomitant damage to normal tissues and organs.
    Citation
    Immunology in the clinic review series; focus on cancer: double trouble for tumours: bi-functional and redirected T cells as effective cancer immunotherapies. 2012, 167 (2):216-25 Clin Exp Immunol
    Journal
    Clinical and Experimental Immunology
    URI
    http://hdl.handle.net/10541/216291
    DOI
    10.1111/j.1365-2249.2011.04517.x
    PubMed ID
    22235997
    Type
    Article
    Language
    en
    ISSN
    1365-2249
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2249.2011.04517.x
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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