Prognostic value of a combined estrogen receptor, progesterone receptor, Ki-67, and human epidermal growth factor receptor 2 immunohistochemical score and comparison with the Genomic Health recurrence score in early breast cancer.
Authors
Cuzick, JDowsett, M
Pineda, S
Wale, C
Salter, J
Quinn, E
Zabaglo, L
Mallon, E
Green, A R
Ellis, I O
Howell, Anthony
Buzdar, A U
Forbes, J F
Affiliation
Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom.Issue Date
2011-11-10
Metadata
Show full item recordAbstract
We recently reported that the mRNA-based, 21-gene Genomic Health recurrence score (GHI-RS) provided additional prognostic information regarding distant recurrence beyond that obtained from classical clinicopathologic factors (age, nodal status, tumor size, grade, endocrine treatment) in women with early breast cancer, confirming earlier reports. The aim of this article is to determine how much of this information is contained in standard immunohistochemical (IHC) markers.Citation
Prognostic value of a combined estrogen receptor, progesterone receptor, Ki-67, and human epidermal growth factor receptor 2 immunohistochemical score and comparison with the Genomic Health recurrence score in early breast cancer. 2011, 29 (32):4273-8 J Clin OncolJournal
Journal of Clinical OncologyDOI
10.1200/JCO.2010.31.2835PubMed ID
21990413Type
ArticleLanguage
enISSN
1527-7755ae974a485f413a2113503eed53cd6c53
10.1200/JCO.2010.31.2835