Intra-abdominal Clear-Cell Sarcoma: A Report of 3 Cases, Including 1 Case With Unusual Morphological Features, and Review of the Literature.
dc.contributor.author | Shenjere, Patrick | |
dc.contributor.author | Salman, W D | |
dc.contributor.author | Singh, M | |
dc.contributor.author | Mangham, D C | |
dc.contributor.author | Williams, A | |
dc.contributor.author | Eyden, Brian P | |
dc.contributor.author | Howard, N | |
dc.contributor.author | Knight, B | |
dc.contributor.author | Banerjee, Saumitra S | |
dc.date.accessioned | 2012-03-20T12:54:21Z | |
dc.date.available | 2012-03-20T12:54:21Z | |
dc.date.issued | 2011-11-13 | |
dc.identifier.citation | Intra-abdominal Clear-Cell Sarcoma: A Report of 3 Cases, Including 1 Case With Unusual Morphological Features, and Review of the Literature. 2011: Int J Surg Pathol | en_GB |
dc.identifier.issn | 1940-2465 | |
dc.identifier.pmid | 22084426 | |
dc.identifier.doi | 10.1177/1066896911425485 | |
dc.identifier.uri | http://hdl.handle.net/10541/216130 | |
dc.description.abstract | Clear-cell sarcoma (CCS) is a soft-tissue neoplasm that morphologically resembles cutaneous malignant melanoma but has a distinct molecular profile. Gastrointestinal and intra-abdominal CCSs are very rare. Here, the authors present 3 cases of intra-abdominal CCS and review the literature. Of these cases, 2 involved the small bowel, and 1 involved the peritoneum. Cases 1 and 3 had the characteristic CCS morphology, but case 2 was morphologically unusual and therefore difficult to diagnose. It had relatively small cells with less prominence of clear cells; many pseudoglandular structures were also present. It also showed aberrant expression of epithelial membrane antigen (EMA). The other 2 cases also involved some diagnostic uncertainty and were therefore referred to specialized centers. The authors wish to emphasize the importance of molecular studies in making a conclusive diagnosis of intra-abdominal CCS. | |
dc.language | ENG | |
dc.language.iso | en | en |
dc.rights | Archived with thanks to International journal of surgical pathology | en_GB |
dc.title | Intra-abdominal Clear-Cell Sarcoma: A Report of 3 Cases, Including 1 Case With Unusual Morphological Features, and Review of the Literature. | en |
dc.type | Article | en |
dc.contributor.department | The Christie NHS Foundation Trust, Manchester, UK. | en_GB |
dc.identifier.journal | International Journal of Surgical Pathology | en_GB |
html.description.abstract | Clear-cell sarcoma (CCS) is a soft-tissue neoplasm that morphologically resembles cutaneous malignant melanoma but has a distinct molecular profile. Gastrointestinal and intra-abdominal CCSs are very rare. Here, the authors present 3 cases of intra-abdominal CCS and review the literature. Of these cases, 2 involved the small bowel, and 1 involved the peritoneum. Cases 1 and 3 had the characteristic CCS morphology, but case 2 was morphologically unusual and therefore difficult to diagnose. It had relatively small cells with less prominence of clear cells; many pseudoglandular structures were also present. It also showed aberrant expression of epithelial membrane antigen (EMA). The other 2 cases also involved some diagnostic uncertainty and were therefore referred to specialized centers. The authors wish to emphasize the importance of molecular studies in making a conclusive diagnosis of intra-abdominal CCS. |
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