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dc.contributor.authorShenjere, Patrick
dc.contributor.authorSalman, W D
dc.contributor.authorSingh, M
dc.contributor.authorMangham, D C
dc.contributor.authorWilliams, A
dc.contributor.authorEyden, Brian P
dc.contributor.authorHoward, N
dc.contributor.authorKnight, B
dc.contributor.authorBanerjee, Saumitra S
dc.date.accessioned2012-03-20T12:54:21Z
dc.date.available2012-03-20T12:54:21Z
dc.date.issued2011-11-13
dc.identifier.citationIntra-abdominal Clear-Cell Sarcoma: A Report of 3 Cases, Including 1 Case With Unusual Morphological Features, and Review of the Literature. 2011: Int J Surg Patholen_GB
dc.identifier.issn1940-2465
dc.identifier.pmid22084426
dc.identifier.doi10.1177/1066896911425485
dc.identifier.urihttp://hdl.handle.net/10541/216130
dc.description.abstractClear-cell sarcoma (CCS) is a soft-tissue neoplasm that morphologically resembles cutaneous malignant melanoma but has a distinct molecular profile. Gastrointestinal and intra-abdominal CCSs are very rare. Here, the authors present 3 cases of intra-abdominal CCS and review the literature. Of these cases, 2 involved the small bowel, and 1 involved the peritoneum. Cases 1 and 3 had the characteristic CCS morphology, but case 2 was morphologically unusual and therefore difficult to diagnose. It had relatively small cells with less prominence of clear cells; many pseudoglandular structures were also present. It also showed aberrant expression of epithelial membrane antigen (EMA). The other 2 cases also involved some diagnostic uncertainty and were therefore referred to specialized centers. The authors wish to emphasize the importance of molecular studies in making a conclusive diagnosis of intra-abdominal CCS.
dc.languageENG
dc.language.isoenen
dc.rightsArchived with thanks to International journal of surgical pathologyen_GB
dc.titleIntra-abdominal Clear-Cell Sarcoma: A Report of 3 Cases, Including 1 Case With Unusual Morphological Features, and Review of the Literature.en
dc.typeArticleen
dc.contributor.departmentThe Christie NHS Foundation Trust, Manchester, UK.en_GB
dc.identifier.journalInternational Journal of Surgical Pathologyen_GB
html.description.abstractClear-cell sarcoma (CCS) is a soft-tissue neoplasm that morphologically resembles cutaneous malignant melanoma but has a distinct molecular profile. Gastrointestinal and intra-abdominal CCSs are very rare. Here, the authors present 3 cases of intra-abdominal CCS and review the literature. Of these cases, 2 involved the small bowel, and 1 involved the peritoneum. Cases 1 and 3 had the characteristic CCS morphology, but case 2 was morphologically unusual and therefore difficult to diagnose. It had relatively small cells with less prominence of clear cells; many pseudoglandular structures were also present. It also showed aberrant expression of epithelial membrane antigen (EMA). The other 2 cases also involved some diagnostic uncertainty and were therefore referred to specialized centers. The authors wish to emphasize the importance of molecular studies in making a conclusive diagnosis of intra-abdominal CCS.


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