Intra-abdominal Clear-Cell Sarcoma: A Report of 3 Cases, Including 1 Case With Unusual Morphological Features, and Review of the Literature.
Authors
Shenjere, PatrickSalman, W D
Singh, M
Mangham, D C
Williams, A
Eyden, Brian P
Howard, N
Knight, B
Banerjee, Saumitra S
Affiliation
The Christie NHS Foundation Trust, Manchester, UK.Issue Date
2011-11-13
Metadata
Show full item recordAbstract
Clear-cell sarcoma (CCS) is a soft-tissue neoplasm that morphologically resembles cutaneous malignant melanoma but has a distinct molecular profile. Gastrointestinal and intra-abdominal CCSs are very rare. Here, the authors present 3 cases of intra-abdominal CCS and review the literature. Of these cases, 2 involved the small bowel, and 1 involved the peritoneum. Cases 1 and 3 had the characteristic CCS morphology, but case 2 was morphologically unusual and therefore difficult to diagnose. It had relatively small cells with less prominence of clear cells; many pseudoglandular structures were also present. It also showed aberrant expression of epithelial membrane antigen (EMA). The other 2 cases also involved some diagnostic uncertainty and were therefore referred to specialized centers. The authors wish to emphasize the importance of molecular studies in making a conclusive diagnosis of intra-abdominal CCS.Citation
Intra-abdominal Clear-Cell Sarcoma: A Report of 3 Cases, Including 1 Case With Unusual Morphological Features, and Review of the Literature. 2011: Int J Surg PatholJournal
International Journal of Surgical PathologyDOI
10.1177/1066896911425485PubMed ID
22084426Type
ArticleLanguage
enISSN
1940-2465ae974a485f413a2113503eed53cd6c53
10.1177/1066896911425485
Scopus Count
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