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    The requirement for proteomics to unravel stem cell regulatory mechanisms.

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    Authors
    Williamson, Andrew J K
    Whetton, Anthony D
    Affiliation
    Stem Cell and Leukaemia Proteomics Laboratory, School of Cancer and Enabling Sciences, Manchester Academic Health Science Centre, The University of Manchester, Christie's NHS Foundation Trust, Wolfson Molecular Imaging Centre, Withington, Manchester, UK.
    Issue Date
    2011-10
    
    Metadata
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    Abstract
    Stem cells are defined by their ability to self-renew and to differentiate, the processes whereby these events are achieved is the subject of much investigation. These studies include cancer stem cell populations, where eradication of this specific population is the ultimate goal of treatment. Whilst cellular signalling events and transcription factor complex-mediated changes in gene expression have been analysed in some detail within stem cells, full systematic understanding of the events promoting self-renewal or the commitment process leading to formation of a specific cell type require a systems biology approach. This in turn demands a need for proteomic analysis of post-translational regulation of protein levels, protein interactions, protein post-translational modification (e.g. ubiquitination, methylation, acetylation, phosphorylation) to identify networks for stem cell regulation. Furthermore, the phenomenon of induced pluripotency via cellular reprogramming also can be understood optimally using combined molecular biology and proteomics approaches; here we describe current research employing proteomics and mass spectrometry to dissect stem cell regulatory mechanisms.
    Citation
    The requirement for proteomics to unravel stem cell regulatory mechanisms. 2011, 226 (10):2478-83 J. Cell. Physiol.
    Journal
    Journal of Cellular Physiology
    URI
    http://hdl.handle.net/10541/201132
    DOI
    10.1002/jcp.22610
    PubMed ID
    21792904
    Type
    Article
    Language
    en
    ISSN
    1097-4652
    ae974a485f413a2113503eed53cd6c53
    10.1002/jcp.22610
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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