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dc.contributor.authorNaidoo, Khimara
dc.contributor.authorClay, V
dc.contributor.authorHoyland, J A
dc.contributor.authorSwindell, Ric
dc.contributor.authorLinton, Kim M
dc.contributor.authorIllidge, Timothy M
dc.contributor.authorRadford, John A
dc.contributor.authorByers, RJ
dc.date.accessioned2012-01-09T22:43:58Z
dc.date.available2012-01-09T22:43:58Z
dc.date.issued2011-02
dc.identifier.citationYY1 expression predicts favourable outcome in follicular lymphoma. 2011, 64 (2):125-9 J. Clin. Pathol.en
dc.identifier.issn1472-4146
dc.identifier.pmid21109702
dc.identifier.doi10.1136/jcp.2010.078188
dc.identifier.urihttp://hdl.handle.net/10541/201091
dc.description.abstractFollicular lymphoma is the second most common type of non-Hodgkin's lymphoma worldwide. The majority of patients diagnosed as having follicular lymphoma have an indolent form of the disease, but a subset of patients have aggressive disease with a shorter survival interval. Optimal treatment stratification requires a distinction between these two groups, though there are presently few prognostic biomarkers available. The transcription factor YY1 has been shown to play an important role in cancer biology. The authors have previously reported a correlation of Yin Yang 1 (YY1) mRNA levels with survival in FL. This study aimed to validate these findings at the protein level.
dc.language.isoenen
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshHumans
dc.subject.meshKaplan-Meier Estimate
dc.subject.meshKi-67 Antigen
dc.subject.meshLymphoma, Follicular
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasm Proteins
dc.subject.meshPrognosis
dc.subject.meshTumor Markers, Biological
dc.subject.meshYY1 Transcription Factor
dc.titleYY1 expression predicts favourable outcome in follicular lymphoma.en
dc.typeArticleen
dc.contributor.departmentSchool of Cancer and Enabling Sciences, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK.en
dc.identifier.journalJournal of Clinical Pathologyen
html.description.abstractFollicular lymphoma is the second most common type of non-Hodgkin's lymphoma worldwide. The majority of patients diagnosed as having follicular lymphoma have an indolent form of the disease, but a subset of patients have aggressive disease with a shorter survival interval. Optimal treatment stratification requires a distinction between these two groups, though there are presently few prognostic biomarkers available. The transcription factor YY1 has been shown to play an important role in cancer biology. The authors have previously reported a correlation of Yin Yang 1 (YY1) mRNA levels with survival in FL. This study aimed to validate these findings at the protein level.


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