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dc.contributor.authorDanson, Sarah
dc.contributor.authorJohnson, P
dc.contributor.authorWard, Timothy H
dc.contributor.authorDawson, M
dc.contributor.authorDenneny, Olive
dc.contributor.authorDickinson, G
dc.contributor.authorAarons, Leon
dc.contributor.authorWatson, A
dc.contributor.authorJowle, Debra
dc.contributor.authorCummings, Jeffrey
dc.contributor.authorRobson, L
dc.contributor.authorHalbert, G
dc.contributor.authorDive, Caroline
dc.contributor.authorRanson, Malcolm R
dc.date.accessioned2012-01-09T14:17:37Z
dc.date.available2012-01-09T14:17:37Z
dc.date.issued2011-07
dc.identifier.citationPhase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1. 2011, 22 (7):1653-60 Ann. Oncol.en
dc.identifier.issn1569-8041
dc.identifier.pmid21378203
dc.identifier.doi10.1093/annonc/mdq638
dc.identifier.urihttp://hdl.handle.net/10541/200921
dc.description.abstractThis trial describes a first-in-man evaluation of RH1, a novel bioreductive drug activated by DT-diaphorase (DTD), an enzyme overexpressed in many tumours.
dc.language.isoenen
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAziridines
dc.subject.meshBenzoquinones
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMaximum Tolerated Dose
dc.subject.meshMiddle Aged
dc.subject.meshNAD(P)H Dehydrogenase (Quinone)
dc.subject.meshNeoplasms
dc.subject.meshPolymorphism, Genetic
dc.subject.meshRetrospective Studies
dc.subject.meshTissue Distribution
dc.subject.meshTreatment Outcome
dc.titlePhase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Oncology, University of Manchester, Christie Hospital NHS Foundation Trust, Manchester, UK.en
dc.identifier.journalAnnals of Oncologyen
html.description.abstractThis trial describes a first-in-man evaluation of RH1, a novel bioreductive drug activated by DT-diaphorase (DTD), an enzyme overexpressed in many tumours.


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