Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1.

Authors
Danson, Sarah
Johnson, P
Ward, Timothy H
Dawson, M
Denneny, Olive
Dickinson, G
Aarons, Leon
Watson, A
Jowle, Debra
Cummings, Jeffrey
Affiliation
Department of Medical Oncology, University of Manchester, Christie Hospital NHS Foundation Trust, Manchester, UK.
Issue Date
2011-07

Metadata
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Abstract
This trial describes a first-in-man evaluation of RH1, a novel bioreductive drug activated by DT-diaphorase (DTD), an enzyme overexpressed in many tumours.
Citation
Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1. 2011, 22 (7):1653-60 Ann. Oncol.
Journal
Annals of Oncology
URI
http://hdl.handle.net/10541/200921
DOI
10.1093/annonc/mdq638
PubMed ID
21378203
Type
Article
Language
en
ISSN
1569-8041
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