Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1.
Ward, Timothy H
Ranson, Malcolm R
AffiliationDepartment of Medical Oncology, University of Manchester, Christie Hospital NHS Foundation Trust, Manchester, UK.
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AbstractThis trial describes a first-in-man evaluation of RH1, a novel bioreductive drug activated by DT-diaphorase (DTD), an enzyme overexpressed in many tumours.
CitationPhase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1. 2011, 22 (7):1653-60 Ann. Oncol.
JournalAnnals of Oncology