Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1.
Authors
Danson, SarahJohnson, P
Ward, Timothy H
Dawson, M
Denneny, Olive
Dickinson, G
Aarons, Leon
Watson, A
Jowle, Debra
Cummings, Jeffrey
Robson, L
Halbert, G
Dive, Caroline
Ranson, Malcolm R
Affiliation
Department of Medical Oncology, University of Manchester, Christie Hospital NHS Foundation Trust, Manchester, UK.Issue Date
2011-07
Metadata
Show full item recordAbstract
This trial describes a first-in-man evaluation of RH1, a novel bioreductive drug activated by DT-diaphorase (DTD), an enzyme overexpressed in many tumours.Citation
Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1. 2011, 22 (7):1653-60 Ann. Oncol.Journal
Annals of OncologyDOI
10.1093/annonc/mdq638PubMed ID
21378203Type
ArticleLanguage
enISSN
1569-8041ae974a485f413a2113503eed53cd6c53
10.1093/annonc/mdq638
Scopus Count
Related articles
- Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice.
- Authors: Loadman PM, Phillips RM, Lim LE, Bibby MC
- Issue date: 2000 Apr 1
- Development of a new isogenic cell-xenograft system for evaluation of NAD(P)H:quinone oxidoreductase-directed antitumor quinones: evaluation of the activity of RH1.
- Authors: Dehn DL, Winski SL, Ross D
- Issue date: 2004 May 1
- Preclinical evaluation of the pharmacodynamic properties of 2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone.
- Authors: Ward TH, Danson S, McGown AT, Ranson M, Coe NA, Jayson GC, Cummings J, Hargreaves RH, Butler J
- Issue date: 2005 Apr 1
- Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones.
- Authors: Winski SL, Swann E, Hargreaves RH, Dehn DL, Butler J, Moody CJ, Ross D
- Issue date: 2001 Jun 15
- Cytotoxicity of the bioreductive agent RH1 and its lack of interaction with radiation.
- Authors: Kim JY, West CM, Valentine H, Ward TH, Patterson AV, Stratford IJ, Roberts SA, Hendry JH
- Issue date: 2004 Mar