Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1.
Authors
Danson, SarahJohnson, P
Ward, Timothy H
Dawson, M
Denneny, Olive
Dickinson, G
Aarons, Leon
Watson, A
Jowle, Debra
Cummings, Jeffrey
Robson, L
Halbert, G
Dive, Caroline
Ranson, Malcolm R
Affiliation
Department of Medical Oncology, University of Manchester, Christie Hospital NHS Foundation Trust, Manchester, UK.Issue Date
2011-07
Metadata
Show full item recordAbstract
This trial describes a first-in-man evaluation of RH1, a novel bioreductive drug activated by DT-diaphorase (DTD), an enzyme overexpressed in many tumours.Citation
Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1. 2011, 22 (7):1653-60 Ann. Oncol.Journal
Annals of OncologyDOI
10.1093/annonc/mdq638PubMed ID
21378203Type
ArticleLanguage
enISSN
1569-8041ae974a485f413a2113503eed53cd6c53
10.1093/annonc/mdq638
Scopus Count
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