A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours.
Authors
Khan, O AGore, M
Lorigan, Paul C
Stone, J
Greystoke, Alastair
Burke, W
Carmichael, J
Watson, Amanda J
McGown, Gail
Thorncroft, Mary R
Margison, Geoffrey P
Califano, Raffaele
Larkin, J
Wellman, S
Middleton, M R
Affiliation
University of Oxford Department of Oncology, Churchill Hospital, Old Road, Oxford OX3 7LJ, UK.Issue Date
2011-03-01
Metadata
Show full item recordAbstract
Poly adenosine diphosphate (ADP)-ribose polymerase (PARP) is essential in cellular processing of DNA damage via the base excision repair pathway (BER). The PARP inhibition can be directly cytotoxic to tumour cells and augments the anti-tumour effects of DNA-damaging agents. This study evaluated the optimally tolerated dose of olaparib (4-(3--4-fluorophenyl) methyl-1(2H)-one; AZD2281, KU0059436), a potent PARP inhibitor, with dacarbazine and assessed safety, toxicity, clinical pharmacokinetics and efficacy of combination treatment.Citation
A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours. 2011, 104 (5):750-5 Br. J. CancerJournal
British Journal of CancerDOI
10.1038/bjc.2011.8PubMed ID
21326243PubMed Central ID
PMC3048218Type
ArticleLanguage
enISSN
1532-1827ae974a485f413a2113503eed53cd6c53
10.1038/bjc.2011.8
Scopus Count
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