On the theory of clonal selection in carcinogenic transformation.
AffiliationPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
MetadataShow full item record
AbstractA temperature sensitive variant (ts13) of African green monkey kidney cell line, carrying a temperature sensitive lesion in thymidine metabolism, was transformed by 40 μg/ml of methylnitrosourea (MNU) at the restricted temperature of 39·5°C, whereas the same cell line was not transformed by MNU at the permissive temperature of 33°C. Results presented in this paper raise the possibility that clones of cells carrying a biochemical lesion might possibly contribute to carcinogenesis with respect to certain chemical carcinogens.
CitationOn the theory of clonal selection in carcinogenic transformation. 1974, 30 (5):448-58 Br. J. Cancer
JournalBritish Journal of Cancer
PubMed Central IDPMC2009312
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