Growth impairment in children treated for brain tumours.

Shalet, Stephen M; Beardwell, Colin G; Aarons, B M; Pearson, D; Morris Jones, P H

dc.contributor.author	Shalet, Stephen M
dc.contributor.author	Beardwell, Colin G
dc.contributor.author	Aarons, B M
dc.contributor.author	Pearson, D
dc.contributor.author	Morris Jones, P H
dc.date.accessioned	2012-01-04T22:52:05Z
dc.date.available	2012-01-04T22:52:05Z
dc.date.issued	1978-06
dc.identifier.citation	Growth impairment in children treated for brain tumours. 1978, 53 (6):491-4 Arch. Dis. Child.	en
dc.identifier.issn	1468-2044
dc.identifier.pmid	686776
dc.identifier.doi	10.1136/adc.53.6.491
dc.identifier.uri	http://hdl.handle.net/10541/200131
dc.description.abstract	Growth and growth hormone (GH) secretion were studied in 14 children with brain tumours before radiation and chemotherapy and at various time intervals afterwards. The peak GH response to hypoglycaemia was normal in all patients before radiation. In 6 patients the peak GH response was impaired 1 year after radiation, and in a seventh it was normal at 1 year but impaired 2 years after radiation. In 12 of 13 patients the growth velocity during the first year of chemotherapy was below the 3rd centile, although none of these had an initial standing height below the 3rd centile. Thus it appears that poor growth in such children occurs irrespective of whether radiation-induced GH deficiency develops. The cause of this impaired growth is unknown.
dc.language.iso	en	en
dc.subject.mesh	Adolescent
dc.subject.mesh	Brain Neoplasms
dc.subject.mesh	Child
dc.subject.mesh	Child, Preschool
dc.subject.mesh	Female
dc.subject.mesh	Growth Disorders
dc.subject.mesh	Growth Hormone
dc.subject.mesh	Humans
dc.subject.mesh	Infant
dc.subject.mesh	Insulin
dc.subject.mesh	Male
dc.subject.mesh	Secretory Rate
dc.title	Growth impairment in children treated for brain tumours.	en
dc.type	Article	en
dc.contributor.department	Christie Hospital, Withington, Manchester, M20 4BX, UK	en
dc.identifier.journal	Archives of Disease in Childhood	en
refterms.dateFOA	2020-04-20T14:10:31Z
html.description.abstract	Growth and growth hormone (GH) secretion were studied in 14 children with brain tumours before radiation and chemotherapy and at various time intervals afterwards. The peak GH response to hypoglycaemia was normal in all patients before radiation. In 6 patients the peak GH response was impaired 1 year after radiation, and in a seventh it was normal at 1 year but impaired 2 years after radiation. In 12 of 13 patients the growth velocity during the first year of chemotherapy was below the 3rd centile, although none of these had an initial standing height below the 3rd centile. Thus it appears that poor growth in such children occurs irrespective of whether radiation-induced GH deficiency develops. The cause of this impaired growth is unknown.