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    Management of congenital adrenal hyperplasia. Urinary steroid estimations--review of their value.

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    Authors
    Bailey, C C
    Komrower, G M
    Palmer, Michael K
    Affiliation
    Christie Hospital, Withington, Manchester, M20 4BX, UK
    Issue Date
    1978-02
    
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    Abstract
    A retrospective study was made of 16 children with 21-hydroxylase-deficient congenital adrenal hyperplasia of the salt-losing variety, who were treated with fludrocortisone and prednisone and were in good health during the period under review. The height velocity of the children was subnormal, height achievement was poor, and their bone ages retarded. Urinary 17-oxosteroid and pregnanetriol excretion were used to monitor the therapy of the children and these data have been related to growth velocities. In spite of urinary steroid figures in excess of those published as desirable for monitoring therapy, the children failed to grow properly, probably as a result of glucocorticoid overdosage. Published urinary steroid criteria are considered too strict and in order to achieve them one would need to give unnecessarily high doses of steroid. Regular measurement of height velocity and skeletal maturation rate are better indicators of therapeutic control and should lead to more satisfactory growth and ultimate height.
    Citation
    Management of congenital adrenal hyperplasia. Urinary steroid estimations--review of their value. 1978, 53 (2):132-5 Arch. Dis. Child.
    Journal
    Archives of Disease in Childhood
    URI
    http://hdl.handle.net/10541/199550
    DOI
    10.1136/adc.53.2.132
    PubMed ID
    646414
    Type
    Article
    Language
    en
    ISSN
    1468-2044
    ae974a485f413a2113503eed53cd6c53
    10.1136/adc.53.2.132
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