The incorporation of wrong bases by DNA polymerase I following gamma-irradiation of DNA-like templates.
Authors
Saffhill, RoyAffiliation
Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, Great Britain.Issue Date
1974-04-27
Metadata
Show full item recordAbstract
The synthesis of polydeoxyribose polymers by Escherichia coli DNA polymerase I has been investigated with control and gamma-irradiated DNA-like polymer templates containing only two bases. The results show that irradiation of a poly(dA) strand leads to the incorporation of dG, whereas irradiation of poly(dC) and poly(dG) strands both lead to the incorporation of dA. Irradiation of poly(dT) does not lead to the incorporation of any wrong base. The wrong bases are incorporated into the complementary strand of the newly synthesised DNA.Citation
The incorporation of wrong bases by DNA polymerase I following gamma-irradiation of DNA-like templates. 1974, 349 (1):23-31 Biochim. Biophys. ActaJournal
Biochimica et Biophysica ActaPubMed ID
11400434Type
ArticleLanguage
enISSN
0006-3002Collections
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