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    The steepness of the dose response curve both for tumor cure and normal tissue injury.

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    Authors
    Stewart, J G
    Jackson, A W
    Affiliation
    Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1975-07
    
    Metadata
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    Abstract
    At the Christie Hospital in Manchester, 4 MeV radiation was introduced in 1955. In consequence of a lack of knowledge of absolute dose definition and R.B.E. factor, patients were treated over a range of dosage. Three hundred fourteen patients with laryngeal cancer, treated over a time interval of three weeks, received doses over a range of 5,000 rad to 5,800 rads. Recurrence, morbidity and necrosis rates are plotted against dose. In T1 tumors there is very little variation in recurrence rate, and such tumors may be safely treated at the lower doses thus avoiding morbidity and necrosis. T3 tumors, however, show a considerable variation in recurrence rate being 68 percent at the lower end of the range, dropping to 30 percent at the high end. Necrosis nil at the lower end rises to some 8 percent at the high end. The balance of advantage of tumor sterilization versus the disadvantage of normal tissue damage is discussed.
    Citation
    The steepness of the dose response curve both for tumor cure and normal tissue injury. 1975, 85 (7):1107-11 Laryngoscope
    Journal
    Laryngoscope
    URI
    http://hdl.handle.net/10541/199372
    DOI
    10.1288/00005537-197507000-00001
    PubMed ID
    807783
    Type
    Article
    Language
    en
    ISSN
    0023-852X
    ae974a485f413a2113503eed53cd6c53
    10.1288/00005537-197507000-00001
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