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    Heterogeneous distribution of DNA alkylation products in rat liver chromatin after in vivo administration of N,N-di[14C]methylnitrosamine.

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    Authors
    Cooper, H K
    Margison, Geoffrey P
    O'Connor, Peter J
    Itzhaki, Ruth F
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1975-12
    
    Metadata
    Show full item record
    Abstract
    Poly-l-lysine (PL) binds to about 50% of chromatin DNA, rendering it resistant to degradation by DNAase I. Separation of the unbound DNA as acid-soluble nucleotides allows the fractionation of chromatin DNA into two zones. After in vivo administration of N,N-di[14C]methylnitrosamine, the amount of alkylation in DNA was found to be lower in the polylysine-binding regions. Some possible reasons for this heterogeneous distribution are discussed.
    Citation
    Heterogeneous distribution of DNA alkylation products in rat liver chromatin after in vivo administration of N,N-di[14C]methylnitrosamine. 1975, 11 (6):483-92 Chem. Biol. Interact.
    Journal
    Chemico-Biological Interactions
    URI
    http://hdl.handle.net/10541/199370
    DOI
    10.1016/0009-2797(75)90024-1
    PubMed ID
    1201613
    Type
    Article
    Language
    en
    ISSN
    0009-2797
    ae974a485f413a2113503eed53cd6c53
    10.1016/0009-2797(75)90024-1
    Scopus Count
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    All Paterson Institute for Cancer Research

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