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    Kinetics and possible regulation of crypt cell populations under normal and stress conditions.

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    Authors
    Potten, Christopher S
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester
    Issue Date
    1975
    
    Metadata
    Show full item record
    Abstract
    The proliferative organisation of the crypts of the small intestine is considered with special reference to the existence, location and numbers of stem cells. It is concluded that the crypt contains a minority population of cells at its base that are the true stem cells. These cells provide an input of cells for the larger proliferative compartment higher up the crypt. The presumptive stem cells may be pluripotent and produce Paneth, goblet and columnar cells. They are probably also the cells which are capable of regenerating the crypt after X-ray depopulation. Radiobiological experiments indicate that the number of cryptogenic cells is less than 80, while the results of several experiments on the kinetics of the cell populations indicate that the number of stem cells is about 20. The stem cells are located in the Paneth cell zone of the crypt, and are apparently passing through the cell cycle at about half the speed of the proliferative cells. It is these vital stem cells that will determine the response of the mucosa to therapeutic agents, probably play a role in carcinogenesis and play a dominant role in mechanisms controlling cell proliferation.
    Citation
    Kinetics and possible regulation of crypt cell populations under normal and stress conditions., 62 (4):419-30 Bull Cancer
    Journal
    Bulletin Du Cancer
    URI
    http://hdl.handle.net/10541/199349
    PubMed ID
    1212526
    Type
    Article
    Language
    en
    ISSN
    0007-4551
    Collections
    All Paterson Institute for Cancer Research

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