Current management practices for acromegaly: an international survey.
Bronstein, M D
Casanueva, F F
Ho, K K Y
Trainer, Peter J
AffiliationDepartment of Medical and Surgical Sciences, University of Brescia, Endocrine Service, Montichiari Hospital, Via Ciotti 154, 25018 Montichiari, Italy.
MetadataShow full item record
AbstractTo determine whether peer-reviewed consensus statements have changed clinical practice, we surveyed acromegaly care in specialist centers across the globe, and determined the degree of adherence to published consensus guidelines on acromegaly management. Sixty-five acromegaly experts who participated in the 7th Acromegaly Consensus Workshop in March 2009 responded. Results indicated that the most common referring sources for acromegaly patients were other endocrinologists (in 26% of centers), neurosurgeons (25%) and primary care physicians (21%). In sixty-nine percent of patients, biochemical diagnoses were made by evaluating results of a combination of growth hormone (GH) nadir/basal GH and elevated insulin like growth factor-I (IGF-I) levels. In both Europe and the USA, neurosurgery was the treatment of choice for GH-secreting microadenomas and for macroadenomas with compromised visual function. The most widely used criteria for neurosurgical outcome assessment were combined measurements of IGF-I and GH levels after oral glucose tolerance test (OGTT) 3 months after surgery. Ninety-eight percent of respondents stated that primary treatment with somatostatin receptor ligands (SRLs) was indicated at least sometime during the management of acromegaly patients. In nearly all centers (96%), the use of pegvisomant monotherapy was restricted to patients who had failed to achieve biochemical control with SRL therapy. The observation that most centers followed consensus statement recommendations encourages the future utility of these workshops aimed to create uniform management standards for acromegaly.
CitationCurrent management practices for acromegaly: an international survey. 2011, 14 (2):125-33 Pituitary
- Management of acromegaly: an exploratory survey of physicians from the Middle East and North Africa.
- Authors: Ahmad MM, Buhary BM, Al Mousawi F, Alshahrani F, Brema I, Al Dahmani KM, Beshyah SA, AlMalki MH
- Issue date: 2018 Sep
- Impact of tumor characteristics and pre- and postoperative hormone levels on hormonal remission following endoscopic transsphenoidal surgery in patients with acromegaly.
- Authors: Cardinal T, Rutkowski MJ, Micko A, Shiroishi M, Jason Liu CS, Wrobel B, Carmichael J, Zada G
- Issue date: 2020 Jun
- Authors: Scacchi M, Cavagnini F
- Issue date: 2006
- Daily life reflections of acromegaly guidelines.
- Authors: Apaydin T, Ozkaya HM, Keskin FE, Haliloglu OA, Karababa K, Erdem S, Kadioglu P
- Issue date: 2017 Mar
- AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY DISEASE STATE CLINICAL REVIEW: MANAGEMENT OF ACROMEGALY PATIENTS: WHAT IS THE ROLE OF PRE-OPERATIVE MEDICAL THERAPY?
- Authors: Fleseriu M, Hoffman AR, Katznelson L, AACE Neuroendocrine and Pituitary Scientific Committee.
- Issue date: 2015 Jun