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    Current management practices for acromegaly: an international survey.

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    Authors
    Giustina, A
    Bronstein, M D
    Casanueva, F F
    Chanson, P
    Ghigo, E
    Ho, K K Y
    Klibanski, A
    Lamberts, S
    Trainer, Peter J
    Melmed, S
    Affiliation
    Department of Medical and Surgical Sciences, University of Brescia, Endocrine Service, Montichiari Hospital, Via Ciotti 154, 25018 Montichiari, Italy.
    Issue Date
    2011-06
    
    Metadata
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    Abstract
    To determine whether peer-reviewed consensus statements have changed clinical practice, we surveyed acromegaly care in specialist centers across the globe, and determined the degree of adherence to published consensus guidelines on acromegaly management. Sixty-five acromegaly experts who participated in the 7th Acromegaly Consensus Workshop in March 2009 responded. Results indicated that the most common referring sources for acromegaly patients were other endocrinologists (in 26% of centers), neurosurgeons (25%) and primary care physicians (21%). In sixty-nine percent of patients, biochemical diagnoses were made by evaluating results of a combination of growth hormone (GH) nadir/basal GH and elevated insulin like growth factor-I (IGF-I) levels. In both Europe and the USA, neurosurgery was the treatment of choice for GH-secreting microadenomas and for macroadenomas with compromised visual function. The most widely used criteria for neurosurgical outcome assessment were combined measurements of IGF-I and GH levels after oral glucose tolerance test (OGTT) 3 months after surgery. Ninety-eight percent of respondents stated that primary treatment with somatostatin receptor ligands (SRLs) was indicated at least sometime during the management of acromegaly patients. In nearly all centers (96%), the use of pegvisomant monotherapy was restricted to patients who had failed to achieve biochemical control with SRL therapy. The observation that most centers followed consensus statement recommendations encourages the future utility of these workshops aimed to create uniform management standards for acromegaly.
    Citation
    Current management practices for acromegaly: an international survey. 2011, 14 (2):125-33 Pituitary
    Journal
    Pituitary
    URI
    http://hdl.handle.net/10541/199111
    DOI
    10.1007/s11102-010-0269-9
    PubMed ID
    21063787
    Type
    Article
    Language
    en
    ISSN
    1573-7403
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11102-010-0269-9
    Scopus Count
    Collections
    All Christie Publications
    Endocrinology

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