Affiliation
University of Manchester, Manchester, UK.Issue Date
2011-05-15
Metadata
Show full item recordAbstract
Rac is a member of the Rho family of small GTPases, which act as molecular switches to control a wide array of cellular functions. In particular, Rac signaling has been implicated in the control of cell-cell adhesions, cell-matrix adhesions, cell migration, cell cycle progression and cellular transformation. As a result of its functional diversity, Rac signaling can influence several aspects of tumorigenesis. Consistent with this, in vivo evidence that Rac signaling contributes to tumorigenesis is continuously emerging. Additionally, our understanding of the mechanisms by which Rac signaling is regulated is rapidly expanding and consequently adds to the complexity of how Rac signaling could be modulated during tumorigenesis. Here we review the numerous biological functions and regulatory mechanisms of Rac signaling and discuss how they could influence the different stages of tumorigenesis.Citation
The diverse roles of Rac signaling in tumorigenesis. 2011, 10 (10):1571-81 Cell CycleJournal
Cell CyclePubMed ID
21478669Type
ArticleLanguage
enISSN
1551-4005Collections
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