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    The diverse roles of Rac signaling in tumorigenesis.

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    Authors
    Mack, Natalie A
    Whalley, Helen J
    Castillo-Lluva, Sonia
    Malliri, Angeliki
    Affiliation
    University of Manchester, Manchester, UK.
    Issue Date
    2011-05-15
    
    Metadata
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    Abstract
    Rac is a member of the Rho family of small GTPases, which act as molecular switches to control a wide array of cellular functions. In particular, Rac signaling has been implicated in the control of cell-cell adhesions, cell-matrix adhesions, cell migration, cell cycle progression and cellular transformation. As a result of its functional diversity, Rac signaling can influence several aspects of tumorigenesis. Consistent with this, in vivo evidence that Rac signaling contributes to tumorigenesis is continuously emerging. Additionally, our understanding of the mechanisms by which Rac signaling is regulated is rapidly expanding and consequently adds to the complexity of how Rac signaling could be modulated during tumorigenesis. Here we review the numerous biological functions and regulatory mechanisms of Rac signaling and discuss how they could influence the different stages of tumorigenesis.
    Citation
    The diverse roles of Rac signaling in tumorigenesis. 2011, 10 (10):1571-81 Cell Cycle
    Journal
    Cell Cycle
    URI
    http://hdl.handle.net/10541/199109
    PubMed ID
    21478669
    Type
    Article
    Language
    en
    ISSN
    1551-4005
    Collections
    All Paterson Institute for Cancer Research

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